Održavanje minihromozoma

MCM2/3/5 familija
	MCM 21 protein homo24mer Pyrococcus furiosus
Identifikatori
Simbol	MCM
Pfam	PF00493
Pfam klan	CL0023
InterPro	IPR001208
SMART	SM00350
PROSITE	PDOC00662
Dostupne PDB strukture:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	strukturni pregled

Kompleks održavanja mini hromozoma (MCM) sadrži 2-7 heliksa i učestvuje u inicijacionoj i elongacionoj fazi eukariotske replikacije DNK, specifično u formiranju i elongaciji replikacione viljuške. MCM je komponenta prireplikacionog kompleksa, koji je komponenta faktora licenciranja. MCM je heksamer šest srodnih polipeptida (mcm2-7) koji formiraju prstenastu strukturu.^[2]^[3]

Povezano

↑ Borlado LR, Méndez J (February 2008). „CDC6: from DNA replication to cell cycle checkpoints and oncogenesis”. Carcinogenesis 29 (2): 237–43. DOI:10.1093/carcin/bgm268. PMID 18048387.
↑ ^2,0 ^2,1 Cortez D, Glick G, Elledge SJ (July 2004). „Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases”. Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10078–83. DOI:10.1073/pnas.0403410101. PMC 454167. PMID 15210935.
↑ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM (April 2002). „Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus”. J. Biol. Chem. 277 (14): 12118–27. DOI:10.1074/jbc.M200091200. PMID 11821426.

Humphries C (2001-01-12). „Molecular Bureaucrat Tied to Replication Approval Process”. Focus. Harvard Medical, Dental, and Public Health Schools. Arhivirano iz originala na datum 2007-08-31. Pristupljeno 2008-10-03.
3D macromolecular structures of MCM at the EM Data Bank(EMDB)