RFC5

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Replikacioni faktor C (aktivator 1) 5, 36.5kDa
Dostupne strukture
1LFS
Identifikatori
SimboliRFC5; RFC36
Vanjski IDOMIM600407 HomoloGene6730 GeneCards: RFC5 Gene
Pregled RNK izražavanja
PBB GE RFC5 203209 at tn.png
PBB GE RFC5 203210 s at tn.png
PBB GE RFC5 213734 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez598572151
EnsemblENSG00000111445ENSMUSG00000029363
UniProtP40937Q9D0F6
Ref. Sekv. (iRNK)NM_001130112NM_028128
Ref. Sekv. (protein)NP_001123584NP_082404
Lokacija (UCSC)Chr 12:
118.45 - 118.47 Mb
Chr 5:
117.38 - 117.39 Mb
PubMed pretraga[1][2]

Replikacioni faktor C, podjedinica 5 je protein koji je kod ljudi kodiran RFC5 genom[1][2]

Za elongaciju prajmiranog DNK šablona DNK polimerazom delta i DNK polimerazom epsilon neophodni su pomoćni proteini: proliferativni ćelijski nuklearni antigen (PCNA) i replikacioni faktor C (RFC). RFC, takođe poznat kao aktivator 1, je proteinski kompleks koji se sastoji od pet podjedinica sa 140, 40, 38, 37, i 36 kDa. Ovaj gen kodira 36 kDa podjednicu. Ta podjedinica interaguje sa C-terminalnim regionom PCNA. Ona formira sržni kompleks sa 38 i 40 kDa podjedinicama. Sržni kompleks ispoljava ATPaznu aktivnost, koju stimuliše PCNA u in vitro sistemima. Poznate su alternativno splajsovane transcriptne varijante koje kodiraju različite izoforme.[2]

Interakcije[uredi - уреди | uredi izvor]

RFC5 formira interakcije sa BRD4,[3] RFC2,[4][5] PCNA,[4][6][7] RFC4[4][5][8][9] i CHTF18.[10]

Reference[uredi - уреди | uredi izvor]

  1. Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K et al. (Jul 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics 25 (1): 274–8. PMID 7774928. doi:10.1016/0888-7543(95)80135-9.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: RFC5 replication factor C (activator 1) 5, 36.5kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5985. 
  3. Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. (United States) 22 (18): 6509–20. ISSN 0270-7306. PMC 135621. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.  Check date values in: |date= (help)
  4. 4,0 4,1 4,2 Cai, J; Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". J. Biol. Chem. (UNITED STATES) 272 (30): 18974–81. ISSN 0021-9258. PMID 9228079. doi:10.1074/jbc.272.30.18974.  Check date values in: |date= (help)
  5. 5,0 5,1 Cai, J; Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). "ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20): 11607–12. ISSN 0027-8424. PMC 21688. PMID 9751713. doi:10.1073/pnas.95.20.11607.  Check date values in: |date= (help)
  6. Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan 1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen". J. Biol. Chem. (UNITED STATES) 272 (3): 1769–76. ISSN 0021-9258. PMID 8999859. doi:10.1074/jbc.272.3.1769.  Check date values in: |date= (help)
  7. Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.  Check date values in: |date= (help)
  8. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.  Check date values in: |date= (help)
  9. Ellison, V; Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. ISSN 0021-9258. PMID 9488738. doi:10.1074/jbc.273.10.5979.  Check date values in: |date= (help)
  10. Bermudez, Vladimir P; Maniwa Yoshimasa, Tappin Inger, Ozato Keiko, Yokomori Kyoko, Hurwitz Jerard (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. ISSN 0027-8424. PMC 193545. PMID 12930902. doi:10.1073/pnas.1434308100.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]