RFC2

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Replikacioni faktor C (aktivator 1) 2, 40kDa
Identifikatori
SimboliRFC2; A1; RFC40
Vanjski IDOMIM600404 MGI1341868 HomoloGene6885 GeneCards: RFC2 Gene
Pregled RNK izražavanja
PBB GE RFC2 1053 at tn.png
PBB GE RFC2 203696 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez598219718
EnsemblENSG00000049541ENSMUSG00000023104
UniProtP35250Q9WUK4
Ref. Sekv. (iRNK)NM_002914NM_020022
Ref. Sekv. (protein)NP_002905NP_064406
Lokacija (UCSC)Chr 7:
73.65 - 73.67 Mb
Chr 5:
134.58 - 134.6 Mb
PubMed pretraga[1][2]

Replikacioni faktor C, podjedinica 2 je protein koji je kod ljudi kodiran RFC2 genom.[1][2][3]

Za elongaciju prajmiranog DNK šablona posredstvom DNK polimeraze delta i epsilon neophodni su pomoćni proteini, proliferišući ćelijski nuklearni antigen (PCNA) i replikacioni faktor C (RFC). RFC, takođe poznat kao aktivator 1, je proteinski kompleks koji se sastoji od pet podjedinica sa 145, 40, 38, 37, i 36.5 kD. Ovaj gen kodira 40 kD podjedinicu, za koju je pokazano da je odgovorna za ATP vezivanje. Brisanje ovog gena je asocirano sa Vilijamsovim sindromom. Alternativno splajsovane transkriptne varijante kodiraju distinktne izoforme.[3]

Interakcije[uredi - уреди | uredi izvor]

RFC2 formira interakcije sa BRD4,[4] CHTF18,[5][6] PCNA,[7][8][9] RFC4[7][10] i RFC5.[7][10]

Reference[uredi - уреди | uredi izvor]

  1. Chen M, Pan ZQ, Hurwitz J (May 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proc Natl Acad Sci U S A 89 (7): 2516–20. PMC 48692. PMID 1313560. doi:10.1073/pnas.89.7.2516. 
  2. Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K et al. (Jul 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics 25 (1): 274–8. PMID 7774928. doi:10.1016/0888-7543(95)80135-9.  Check date values in: |date= (help)
  3. 3,0 3,1 "Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982. 
  4. Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. (United States) 22 (18): 6509–20. ISSN 0270-7306. PMC 135621. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.  Check date values in: |date= (help)
  5. Bermudez, Vladimir P; Maniwa Yoshimasa, Tappin Inger, Ozato Keiko, Yokomori Kyoko, Hurwitz Jerard (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. ISSN 0027-8424. PMC 193545. PMID 12930902. doi:10.1073/pnas.1434308100.  Check date values in: |date= (help)
  6. Merkle, Carolin J; Karnitz Larry M, Henry-Sánchez John T, Chen Junjie (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J. Biol. Chem. (United States) 278 (32): 30051–6. ISSN 0021-9258. PMID 12766176. doi:10.1074/jbc.M211591200.  Check date values in: |date= (help)
  7. 7,0 7,1 7,2 Cai, J; Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". J. Biol. Chem. (UNITED STATES) 272 (30): 18974–81. ISSN 0021-9258. PMID 9228079. doi:10.1074/jbc.272.30.18974.  Check date values in: |date= (help)
  8. Pan, Z Q; Chen M, Hurwitz J (Jan 1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 90 (1): 6–10. ISSN 0027-8424. PMC 45588. PMID 8093561. doi:10.1073/pnas.90.1.6.  Check date values in: |date= (help)
  9. Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.  Check date values in: |date= (help)
  10. 10,0 10,1 Cai, J; Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). "ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20): 11607–12. ISSN 0027-8424. PMC 21688. PMID 9751713. doi:10.1073/pnas.95.20.11607.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]