Faktor licenciranja DNK replikacije MCM3

Iz Wikipedije, slobodne enciklopedije
(Preusmjereno sa MCM3)
Idi na navigaciju Idi na pretragu
edit
Komponenta 3 kompleksa minihromozomskog održavanja
Identifikatori
SimboliMCM3; HCC5; P1-MCM3; P1.h; RLFB
Vanjski IDOMIM602693 MGI101845 HomoloGene1791 GeneCards: MCM3 Gene
EC broj3.6.4.12
Pregled RNK izražavanja
PBB GE MCM3 201555 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez417217215
EnsemblENSG00000112118ENSMUSG00000041859
UniProtP25205P25206
Ref. Sekv. (iRNK)NM_001270472NM_008563
Ref. Sekv. (protein)NP_001257401NP_032589
Lokacija (UCSC)Chr 6:
52.13 - 52.15 Mb
Chr 1:
20.8 - 20.82 Mb
PubMed pretraga[1][2]

Faktor licenciranja DNK replikacije MCM3 je protein koji je kod ljudi kodiran MCM3 genom.[1]

Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prereplikacionog kompleksa (pre-RC). On učestuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK. Ovaj protein formira kompleks sa MCM4, 6, i 7, i pokazano je da reguliše helikaznu aktivnost kompleksa. On direktno dolazi u kontakt sa MCM5/CDC46. Ovaj protein formira interakcije, i biva acetilisan posredstvom MCM3AP, acetiltransferaze asocirane sa hromatinom. Acetilacija ovog proteina inhibira inicijaciju DNK replikacije i progresiju ćelijskog ciklusa.[2]

Interakcije[uredi - уреди | uredi izvor]

MCM3 formira interakcije sa ORC4L,[3] ORC5L,[3] CDC6,[4][5] MCM3AP,[6][7][8] MCM5,[3][9] MCM7,[3][4][10][11] DBF4,[3] MCM2[3] i CDC45-srodan protein.[3]

Reference[uredi - уреди | uredi izvor]

  1. Thommes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R (April 1992). "Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein". Nucleic Acids Res 20 (5): 1069–74. PMC 312092. PMID 1549468. doi:10.1093/nar/20.5.1069. 
  2. "Entrez Gene: MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4172. 
  3. 3,0 3,1 3,2 3,3 3,4 3,5 3,6 Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2. 
  4. 4,0 4,1 Fujita, M; Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. (UNITED STATES) 274 (36): 25927–32. ISSN 0021-9258. PMID 10464337. doi:10.1074/jbc.274.36.25927. 
  5. Méndez, J; Stillman B (November 2000). "Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell. Biol. (UNITED STATES) 20 (22): 8602–12. ISSN 0270-7306. PMC 102165. PMID 11046155. doi:10.1128/MCB.20.22.8602-8612.2000. 
  6. Takei, Yoshinori; Assenberg Magdalena, Tsujimoto Gozoh, Laskey Ronald (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. (United States) 277 (45): 43121–5. ISSN 0021-9258. PMID 12226073. doi:10.1074/jbc.C200442200. 
  7. Kuwahara, K; Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood (UNITED STATES) 95 (7): 2321–8. ISSN 0006-4971. PMID 10733502. 
  8. Takei, Y; Tsujimoto G (August 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. (UNITED STATES) 273 (35): 22177–80. ISSN 0021-9258. PMID 9712829. doi:10.1074/jbc.273.35.22177. 
  9. DaFonseca, C J; Shu F, Zhang J J (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-γ". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. ISSN 0027-8424. PMC 30602. PMID 11248027. doi:10.1073/pnas.061487598. 
  10. Fujita, M; Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. ISSN 0021-9258. PMID 9099751. doi:10.1074/jbc.272.16.10928. 
  11. Fujita, Masatoshi; Ishimi Yukio, Nakamura Hiromu, Kiyono Tohru, Tsurumi Tatsuya (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. (United States) 277 (12): 10354–61. ISSN 0021-9258. PMID 11779870. doi:10.1074/jbc.M111398200. 

Literatura[uredi - уреди | uredi izvor]