Faktor licenciranja DNK replikacije MCM7

Iz Wikipedije, slobodne enciklopedije
(Preusmjereno sa MCM7)
Idi na navigaciju Idi na pretragu
edit
Minichromosome maintenance complex component 7
Identifikatori
SimboliMCM7; CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
Vanjski IDOMIM600592 MGI1298398 HomoloGene4323 GeneCards: MCM7 Gene
EC broj3.6.4.12
Pregled RNK izražavanja
PBB GE MCM7 208795 s at tn.png
PBB GE MCM7 210983 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez417617220
EnsemblENSG00000166508ENSMUSG00000029730
UniProtP33993Q61881
Ref. Sekv. (iRNK)NM_001278595NM_008568
Ref. Sekv. (protein)NP_001265524NP_032594
Lokacija (UCSC)Chr 7:
99.69 - 99.7 Mb
Chr 5:
138.16 - 138.17 Mb
PubMed pretraga[1][2]

Faktor licenciranja DNK replikacije MCM7 je protein koji je kod ljudi kodiran MCM7 genom.[1]

Protein kodiran ovim genom je jedan od visoko konzerviranih proteina mini-hromozomskog održavanja (MCM) koji su esencijalni za inicijaciju replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prireplikacionog kompleksa (pre-RC) i može da učestuje u formiranju replikacionih viljuški i regrutovanju drugih proteina vezanih za DNK replikaciju. MCM kompleks se sastoji od ovog proteina i MCM2, dok 4 i 6 proteini poseduju DNK helikaznu aktivnost, i mogu da deluju kao enzimi DNK odmotavanja. Utvrđeno je da je ciklin D1-zavisna kinaza, CDK4, asocirana sa ovim proteinom, i da može da reguliše vezivanje ovog proteina sa proteinom supresije tumora RB1/RB. Poznate su alternativno splajsovane transkriptne varijante koje kodiraju distinktne izoforme.[2]

Vidi još[uredi - уреди | uredi izvor]

Interakcije[uredi - уреди | uredi izvor]

MCM7 formira interakcije sa replikacionim proteinom A1,[3] ORC3L,[3] retinoblastoma protein,[4] MCM5,[3][5][6] MCM6,[3][5][7][8] ORC1L,[3] ORC2L,[3] ORC5L,[3] MCM4,[5][7][8][9] MCM3,[3][5][10][11] CDC6,[3][10] MNAT1,[12] DBF4,[3] MCM2,[3][5][7][8][13] UBE3A,[14] CDC45-srodni protein[3][15] i CDC7.[3]

Reference[uredi - уреди | uredi izvor]

  1. Nakatsuru S, Sudo K, Nakamura Y (March 1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet Cell Genet 68 (3-4): 226–30. PMID 7842741. doi:10.1159/000133918. 
  2. "Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4176. 
  3. 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2. 
  4. Sterner, J M; Dew-Knight S; Musahl C; Kornbluth S; Horowitz J M (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. (UNITED STATES) 18 (5): 2748–57. ISSN 0270-7306. PMC 110654. PMID 9566894. 
  5. 5,0 5,1 5,2 5,3 5,4 Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. ISSN 0021-9258. PMID 9099751. doi:10.1074/jbc.272.16.10928. 
  6. DaFonseca, C J; Shu F; Zhang J J (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. ISSN 0027-8424. PMC 30602. PMID 11248027. doi:10.1073/pnas.061487598. 
  7. 7,0 7,1 7,2 Yabuta, Norikazu; Kajimura Naoko; Mayanagi Kouta; Sato Michio; Gotow Takahito; Uchiyama Yasuo; Ishimi Yukio; Nojima Hiroshi (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells (England) 8 (5): 413–21. ISSN 1356-9597. PMID 12694531. doi:10.1046/j.1365-2443.2003.00645.x. 
  8. 8,0 8,1 8,2 You, Zhiying; Ishimi Yukio; Masai Hisao; Hanaoka Fumio (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. (United States) 277 (45): 42471–9. ISSN 0021-9258. PMID 12207017. doi:10.1074/jbc.M205769200. 
  9. Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. ISSN 0021-9258. PMID 8798650. doi:10.1074/jbc.271.39.24115. 
  10. 10,0 10,1 Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. (UNITED STATES) 274 (36): 25927–32. ISSN 0021-9258. PMID 10464337. doi:10.1074/jbc.274.36.25927. 
  11. Fujita, Masatoshi; Ishimi Yukio; Nakamura Hiromu; Kiyono Tohru; Tsurumi Tatsuya (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. (United States) 277 (12): 10354–61. ISSN 0021-9258. PMID 11779870. doi:10.1074/jbc.M111398200. 
  12. Wang, Y; Xu F; Hall F L (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. (NETHERLANDS) 484 (1): 17–21. ISSN 0014-5793. PMID 11056214. doi:10.1016/S0014-5793(00)02117-7. 
  13. You, Z; Komamura Y; Ishimi Y (December 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526. 
  14. Kühne, C; Banks L (December 1998). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. (UNITED STATES) 273 (51): 34302–9. ISSN 0021-9258. PMID 9852095. doi:10.1074/jbc.273.51.34302. 
  15. Kukimoto, I; Igaki H; Kanda T (November 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. (GERMANY) 265 (3): 936–43. ISSN 0014-2956. PMID 10518787. doi:10.1046/j.1432-1327.1999.00791.x. 

Literatura[uredi - уреди | uredi izvor]