RNK komponenta telomeraze, takođe poznata ka TERC, je RNK gen prisutan kod eukariota, koji je komponenta telomeraze, enzima koji produžava telomere.[2][3] TERC služe kao šabloni za telomernu replikaciju (reverznu transkripciju) posredstvom telomeraze. Telomerazne RNK se znatno razlikuju po sekvuenci i strukturi između kičmenjaka, trepljara i kvasaca, mada oni imaju zajedničku strukturu 5'pseudočvora u blizini sekvence šablona. Telomerazna RNA kičmenjaka ima 3' H/ACA domen sličan snoRNK.[4][5][6]
Telomeraza je ribonukleoproteinska polimeraza koja održava telomerne krajeve dodavanjem telomernih ponavljanja TTAGGG. Ovo ponavljanje varira među eukariotama. Enzim se sastoji od proteinske komponente (TERT) sa reverzno transkriptaznom aktivnošću, i RNK komponente, kodirane ovim genom, koja služi kao šablon za telomerno ponavljanje. Izaražavanje telomeraze ima ulogu u ćelijskom starenju, te je normalno zastupljeno u postnatalnim somatskim ćelijama u kojima se javlja progresivno skraćivanje telomera. Deregulacija izražavanja telomeraze u somatskim ćelijama može da doprinese onkogenezi. Studije na miševima sugeriraju da telomeraze takođe učestvuju u hromozomalnoj popravci, pošto do novo sinteze telomernih ponavljanja može doći pri dvolančanim prekidima.[7]Homolozi TERC se takođe mogu naći u Gallid herpes virusima.[8]
↑PDB1ymo; Theimer CA, Blois CA, Feigon J (2005). "Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.". Mol Cell17 (5): 671–82. doi:10.1016/j.molcel.2005.01.017. PMID15749017.
↑Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J (September 1995). "The RNA component of human telomerase". Science269 (5228): 1236–41. doi:10.1126/science.7544491. PMID7544491.
↑Lingner, J; Hendrick LL, Cech TR (1994). "Telomerase RNAs of different ciliates have a common secondary structure and a permuted template". Genes Dev8 (16): 1984–1998. doi:10.1101/gad.8.16.1984. PMID7958872.Cite uses deprecated parameter |coauthors= (help)
↑Fragnet, L; Kut E, Rasschaert D (2005). "Comparative functional study of the viral telomerase RNA based on natural mutations". J Biol Chem.280 (25): 23502–23515. doi:10.1074/jbc.M501163200. PMID15811851.Cite uses deprecated parameter |coauthors= (help)
Marrone A, Dokal I (2007). "Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer". Expert reviews in molecular medicine6 (26): 1–23. doi:10.1017/S1462399404008671. PMID15613268.
Yamaguchi H (2007). "Mutations of telomerase complex genes linked to bone marrow failures". Journal of Nippon Medical School = Nihon Ika Daigaku zasshi74 (3): 202–9. doi:10.1272/jnms.74.202. PMID17625368.
Soder AI; Hoare SF; Muire S et al. (1997). "Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting". Genomics41 (2): 293–4. doi:10.1006/geno.1997.4621. PMID9143511.Cite uses deprecated parameter |author-separator= (help)
Zhao JQ; Hoare SF; McFarlane R et al. (1998). "Cloning and characterization of human and mouse telomerase RNA gene promoter sequences". Oncogene16 (10): 1345–50. doi:10.1038/sj.onc.1201892. PMID9546436.Cite uses deprecated parameter |author-separator= (help)
Mitchell JR, Wood E, Collins K (1999). "A telomerase component is defective in the human disease dyskeratosis congenita". Nature402 (6761): 551–5. doi:10.1038/990141. PMID10591218.
Wong KK; Chang S; Weiler SR et al. (2000). "Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation". Nat. Genet.26 (1): 85–8. doi:10.1038/79232. PMID10973255.Cite uses deprecated parameter |author-separator= (help)
Mitchell JR, Collins K (2000). "Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase". Mol. Cell6 (2): 361–71. doi:10.1016/S1097-2765(00)00036-8. PMID10983983.
Imoto I; Pimkhaokham A; Fukuda Y et al. (2001). "SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus". Biochem. Biophys. Res. Commun.286 (3): 559–65. doi:10.1006/bbrc.2001.5428. PMID11511096.Cite uses deprecated parameter |author-separator= (help)
Vulliamy T; Marrone A; Goldman F et al. (2001). "The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita". Nature413 (6854): 432–5. doi:10.1038/35096585. PMID11574891.Cite uses deprecated parameter |author-separator= (help)
Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Res.12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID11942411.
Yang Y; Chen Y; Zhang C et al. (2002). "Nucleolar localization of hTERT protein is associated with telomerase function". Exp. Cell Res.277 (2): 201–9. doi:10.1006/excr.2002.5541. PMID12083802.Cite uses deprecated parameter |author-separator= (help)
Chang JT; Chen YL; Yang HT et al. (2002). "Differential regulation of telomerase activity by six telomerase subunits". Eur. J. Biochem.269 (14): 3442–50. doi:10.1046/j.1432-1033.2002.03025.x. PMID12135483.Cite uses deprecated parameter |author-separator= (help)
Sood AK; Coffin J; Jabbari S et al. (2003). "p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma". Cancer Biol. Ther.1 (5): 511–7. PMID12496479.Cite uses deprecated parameter |author-separator= (help)
