POLD1

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Polimeraza (DNK vođena), delta 1, katalitička podjednica
Identifikatori
SimboliPOLD1; CDC2; CRCS10; POLD
Vanjski IDOMIM174761 MGI97741 HomoloGene2014 GeneCards: POLD1 Gene
EC broj2.7.7.7
Pregled RNK izražavanja
PBB GE POLD1 203422 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez542418971
EnsemblENSG00000062822ENSMUSG00000038644
UniProtP28340P52431
Ref. Sekv. (iRNK)NM_001256849NM_011131
Ref. Sekv. (protein)NP_001243778NP_035261
Lokacija (UCSC)Chr 19:
50.89 - 50.92 Mb
Chr 7:
44.53 - 44.55 Mb
PubMed pretraga[1][2]

Katalitička podjedinica DNK polimeraze delta je enzim koji je kod ljudi kodiran POLD1 genom.[1][2] Ona je komponenta kompleksa DNK polimeraza delta.

POLD1, zajedno sa enzimom POLE, je asocirana sa višestrukim adenomom.[3]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  • Kemper RR, Ahn ER, Zhang P et al. (1992). "Human DNA polymerase delta gene maps to region 19q13.3-q13.4 by in situ hybridization.". Genomics 14 (1): 205–6. PMID 1427831. doi:10.1016/S0888-7543(05)80311-8. 
  • Yang CL, Chang LS, Zhang P et al. (1992). "Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta.". Nucleic Acids Res. 20 (4): 735–45. PMC 312012. PMID 1542570. doi:10.1093/nar/20.4.735. 
  • Popanda O, Thielmann HW (1992). "The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.". Biochim. Biophys. Acta 1129 (2): 155–60. PMID 1730053. doi:10.1016/0167-4781(92)90480-N. 
  • Lee MY, Toomey NL (1987). "Human placental DNA polymerase delta: identification of a 170-kilodalton polypeptide by activity staining and immunoblotting.". Biochemistry 26 (4): 1076–85. PMID 2436659. doi:10.1021/bi00378a014. 
  • Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ (1989). "Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.". Biochemistry 27 (17): 6379–83. PMID 3146346. doi:10.1021/bi00417a028. 
  • Nishida C, Reinhard P, Linn S (1988). "DNA repair synthesis in human fibroblasts requires DNA polymerase delta.". J. Biol. Chem. 263 (1): 501–10. PMID 3335506. 
  • Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).". Genomics 44 (1): 45–51. PMID 9286699. doi:10.1006/geno.1997.4838. 
  • Wu SM, Zhang P, Zeng XR et al. (1998). "Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.". J. Biol. Chem. 273 (16): 9561–9. PMID 9545286. doi:10.1074/jbc.273.16.9561. 
  • Coll JM, Hickey RJ, Cronkey EA et al. (1998). "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.". Oncol. Res. 9 (11-12): 629–39. PMID 9563011. 
  • Fox G, Popanda O, Thielmann HW (1998). "Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.". J. Cancer Res. Clin. Oncol. 123 (11-12): 659–68. PMID 9620226. doi:10.1007/s004320050121. 
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806. doi:10.1074/jbc.274.53.37538. 
  • Mo J, Liu L, Leon A et al. (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.". Biochemistry 39 (24): 7245–54. PMID 10852724. doi:10.1021/bi0000871. 
  • Budworth H, Dianova II, Podust VN, Dianov GL (2002). "Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine.". J. Biol. Chem. 277 (24): 21300–5. PMID 11923315. doi:10.1074/jbc.M201918200. 
  • Ohta S, Shiomi Y, Sugimoto K et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  • Smith RW, Nasheuer HP (2002). "Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.". FEBS Lett. 527 (1-3): 143–6. PMID 12220650. doi:10.1016/S0014-5793(02)03197-6. 
  • Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.". Biochim. Biophys. Acta 1578 (1-3): 59–72. PMID 12393188. doi:10.1016/S0167-4781(02)00497-9. 
  • Xie B, Mazloum N, Liu L et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.". Biochemistry 41 (44): 13133–42. PMID 12403614. doi:10.1021/bi0262707. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Shevelev IV, Ramadan K, Hübscher U (2004). "The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.". ScientificWorldJournal 2: 275–81. PMID 12806015. doi:10.1100/tsw.2002.99.