Replikacioni protein A1

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Replikacioni protein A1‎, 70kDa

PDB prikaz bazira na 1ewi.
Dostupne strukture
1EWI, 1FGU, 1JMC, 1L1O, 2B29, 2B3G, 4IJH, 4IJL, 4IPC, 4IPD, 4IPG, 4IPH
SimboliRPA1; HSSB; MST075; REPA1; RF-A; RP-A; RPA70
Vanjski IDOMIM179835 MGI1915525 HomoloGene2208 GeneCards: RPA1 Gene
Ref. Sekv. (iRNK)NM_002945NM_001164223
Ref. Sekv. (protein)NP_002936NP_001157695
Lokacija (UCSC)Chr 17:
1.73 - 1.8 Mb
Chr 11:
75.3 - 75.35 Mb
PubMed pretraga[1][2]

Replikacioni protein A, 70 kDa DNK vezujuća podjedinica je protein koji je kod ljudi kodiran RPA1 genom.[1]

Interakcije[uredi - уреди | uredi izvor]

Replikacioni protein A1 formira interakcije sa RPA2,[2][3] RPA3,[3][4] MCM6,[5] MCM7,[5] MUTYH,[6] BRCA2,[7] ORC6L,[5] ORC2L,[5] TP53BP1,[8] MCM4,[5] P53,[9][10] XPA,[11] MCM2,[5] TIPIN[12] i protein blum sindroma.[13][14][15]

Reference[uredi - уреди | uredi izvor]

  1. Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (April 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". J Biol Chem 268 (9): 6131–8. PMID 8454588. 
  2. Shao, R G; Cao C X, Zhang H, Kohn K W, Wold M S, Pommier Y (March 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". EMBO J. (ENGLAND) 18 (5): 1397–406. ISSN 0261-4189. PMC 1171229. PMID 10064605. doi:10.1093/emboj/18.5.1397. 
  3. 3,0 3,1 Bochkareva, Elena; Korolev Sergey, Lees-Miller Susan P, Bochkarev Alexey (April 2002). "Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA". EMBO J. (England) 21 (7): 1855–63. ISSN 0261-4189. PMC 125950. PMID 11927569. doi:10.1093/emboj/21.7.1855. 
  4. Bochkareva, E; Frappier L, Edwards A M, Bochkarev A (February 1998). "The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain". J. Biol. Chem. (UNITED STATES) 273 (7): 3932–6. ISSN 0021-9258. PMID 9461578. doi:10.1074/jbc.273.7.3932. 
  5. 5,0 5,1 5,2 5,3 5,4 5,5 Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2. 
  6. Parker, A; Gu Y, Mahoney W, Lee S H, Singh K K, Lu A L (February 2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. (United States) 276 (8): 5547–55. ISSN 0021-9258. PMID 11092888. doi:10.1074/jbc.M008463200. 
  7. Wong, Johnson M S; Ionescu Daniela, Ingles C James (January 2003). "Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2". Oncogene (England) 22 (1): 28–33. ISSN 0950-9232. PMID 12527904. doi:10.1038/sj.onc.1206071. 
  8. Yoo, Eunjae; Kim Byung U, Lee Seung Youn, Cho Chae Hyun, Chung Jay H, Lee Chang-Hun (August 2005). "53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage". Oncogene (England) 24 (35): 5423–30. ISSN 0950-9232. PMID 15856006. doi:10.1038/sj.onc.1208710. 
  9. Romanova, Larisa Y; Willers Henning, Blagosklonny Mikhail V, Powell Simon N (Dec 2004). "The interaction of p53 with replication protein A mediates suppression of homologous recombination". Oncogene (England) 23 (56): 9025–33. ISSN 0950-9232. PMID 15489903. doi:10.1038/sj.onc.1207982.  Check date values in: |date= (help)
  10. Riva, F; Zuco V, Vink A A, Supino R, Prosperi E (Dec 2001). "UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells". Carcinogenesis (England) 22 (12): 1971–8. ISSN 0143-3334. PMID 11751427. doi:10.1093/carcin/22.12.1971.  Check date values in: |date= (help)
  11. Li, L; Lu X, Peterson C A, Legerski R J (October 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690. 
  12. Unsal-Kaçmaz, Keziban; Chastain Paul D, Qu Ping-Ping, Minoo Parviz, Cordeiro-Stone Marila, Sancar Aziz, Kaufmann William K (April 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Mol. Cell. Biol. (United States) 27 (8): 3131–42. ISSN 0270-7306. PMC 1899931. PMID 17296725. doi:10.1128/MCB.02190-06. 
  13. Brosh, R M; Li J L, Kenny M K, Karow J K, Cooper M P, Kureekattil R P, Hickson I D, Bohr V A (August 2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. Chem. (UNITED STATES) 275 (31): 23500–8. ISSN 0021-9258. PMID 10825162. doi:10.1074/jbc.M001557200. 
  14. Opresko, Patricia L; von Kobbe Cayetano, Laine Jean-Philippe, Harrigan Jeanine, Hickson Ian D, Bohr Vilhelm A (October 2002). "Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases". J. Biol. Chem. (United States) 277 (43): 41110–9. ISSN 0021-9258. PMID 12181313. doi:10.1074/jbc.M205396200. 
  15. Moens, Peter B; Kolas Nadine K, Tarsounas Madalena, Marcon Edyta, Cohen Paula E, Spyropoulos Barbara (April 2002). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination". J. Cell. Sci. (England) 115 (Pt 8): 1611–22. ISSN 0021-9533. PMID 11950880. 

Literatura[uredi - уреди | uredi izvor]