Kompleks prepoznavanja mesta početka, podjedinica 2

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Kompleks prepoznavanja mesta početka, podjedinica 2
Identifikatori
SimboliORC2; ORC2L
Vanjski IDOMIM601182 MGI1328306 HomoloGene4512 GeneCards: ORC2 Gene
Pregled RNK izražavanja
PBB GE ORC2L 204853 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez499918393
EnsemblENSG00000115942ENSMUSG00000026037
UniProtQ13416Q60862
Ref. Sekv. (iRNK)NM_006190NM_001025378
Ref. Sekv. (protein)NP_006181NP_001020549
Lokacija (UCSC)Chr 2:
201.77 - 201.83 Mb
Chr 1:
58.46 - 58.51 Mb
PubMed pretraga[1][2]
Origin recognition complex subunit 2
Identifikatori
Simbol ORC2
Pfam PF04084
InterPro IPR007220

Kompleks prepoznavanja mesta početka, podjedinica 2 je protein koji je kod ljudi kodiran ORC2 (ORC2L) genom.[1][2]

Kompleks prepoznavanja mesta početka (ORC) je visoko konzervirani proteinski kompleks sa šest podjedinica koji je esencijalan za inicijaciju replikacije DNK kod eukariotskih ćelija. Istraživanja na kvascu su pokazala da se ORC specifično vezuje za mesto početka replikacije i da služi kao platforma za konstrukciju prereplikacionog kompleksa, koji sadrži dodatne inicijacione faktore kao što su Cdc6 i Mcm proteini. Protein kodiran ovim genom je podjedinica kompleksa prepoznavanja mesta početka. Ovaj protein formira sržni kompleks sa ORC3, ORC4, i ORC5. On takođe ostvaruje interakcije sa CDC45L i MCM10, koji su važni za DNK replikaciju. Za ovaj protein je pokazano da se specifično asocira sa mestom početka replikacije Epstein-Barr virusa u ljudskim ćelijama, i smatra se da je neophodan za DNK replikacju iz mesta početka virusa.[2]

Interakcije[uredi - уреди | uredi izvor]

ORC2 formira interakcije sa ORC1,[3][4][5][6] replikacionim proteinom A1,[3] ORC4,[3][5][7][8] ORC5,[3][5][7][9] ORC3,[3][5][7][10][11] MCM4,[3] CDC6,[3][12] MCM5,[3] MCM6,[3] MCM7,[3] MCM10,[13] DBF4,[3] MCM2[3] i ORC6.[3][5]

Reference[uredi - уреди | uredi izvor]

  1. Takahara K, Bong M, Brevard R, Eddy RL, Haley LL, Sait SJ, Shows TB, Hoffman GG, Greenspan DS (October 1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics 31 (1): 119–122. PMID 8808289. doi:10.1006/geno.1996.0018. 
  2. 2,0 2,1 "Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4999. 
  3. 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–128. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2. 
  4. Fujita, Masatoshi; Ishimi Yukio, Nakamura Hiromu, Kiyono Tohru, Tsurumi Tatsuya (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. (United States) 277 (12): 10354–10361. ISSN 0021-9258. PMID 11779870. doi:10.1074/jbc.M111398200. 
  5. 5,0 5,1 5,2 5,3 5,4 Vashee, S; Simancek P, Challberg M D, Kelly T J (July 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–26673. ISSN 0021-9258. PMID 11323433. doi:10.1074/jbc.M102493200. 
  6. Méndez, Juan; Zou-Yang X Helena, Kim So-Young, Hidaka Masumi, Tansey William P, Stillman Bruce (March 2002). "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication". Mol. Cell (United States) 9 (3): 481–491. ISSN 1097-2765. PMID 11931757. doi:10.1016/S1097-2765(02)00467-7. 
  7. 7,0 7,1 7,2 Dhar, S K; Delmolino L, Dutta A (August 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–29071. ISSN 0021-9258. PMID 11395502. doi:10.1074/jbc.M103078200. 
  8. Quintana, D G; Hou Zh, Thome K C, Hendricks M, Saha P, Dutta A (November 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". J. Biol. Chem. (United States) 272 (45): 28247–28251. ISSN 0021-9258. PMID 9353276. doi:10.1074/jbc.272.45.28247. 
  9. Quintana, D G; Thome K C, Hou Z H, Ligon A H, Morton C C, Dutta A (October 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. (United States) 273 (42): 27137–27145. ISSN 0021-9258. PMID 9765232. doi:10.1074/jbc.273.42.27137. 
  10. Matsuoka, Shuhei; Ballif Bryan A, Smogorzewska Agata, McDonald E Robert, Hurov Kristen E, Luo Ji, Bakalarski Corey E, Zhao Zhenming, Solimini Nicole, Lerenthal Yaniv, Shiloh Yosef, Gygi Steven P, Elledge Stephen J (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science (United States) 316 (5828): 1160–1166. PMID 17525332. doi:10.1126/science.1140321. 
  11. Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron (United States) 23 (1): 45–54. ISSN 0896-6273. PMID 10402192. doi:10.1016/S0896-6273(00)80752-7. 
  12. Méndez, J; Stillman B (November 2000). "Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell. Biol. (United States) 20 (22): 8602–8612. ISSN 0270-7306. PMC 102165. PMID 11046155. doi:10.1128/MCB.20.22.8602-8612.2000. 
  13. Izumi, M; Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon K Y, Hurwitz J, Yatagai F, Hanaoka F (December 2000). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. (ENGLAND) 28 (23): 4769–4777. PMC 115166. PMID 11095689. doi:10.1093/nar/28.23.4769. 

Literatura[uredi - уреди | uredi izvor]