RFC1

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Replikacioni faktor C (aktivator 1) 1, 145kDa

Prikaz baziran na PDB 2EBU.
Dostupne strukture
2EBU, 2K6G, 2K7F
Identifikatori
SimboliRFC1; A1; MHCBFB; PO-GA; RECC1; RFC; RFC140
Vanjski IDOMIM102579 MGI97891 HomoloGene2187 GeneCards: RFC1 Gene
Pregled RNK izražavanja
PBB GE RFC1 208021 s at tn.png
PBB GE RFC1 209085 x at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez598119687
EnsemblENSG00000035928ENSMUSG00000029191
UniProtP35251P35601
Ref. Sekv. (iRNK)NM_001204747NM_011258
Ref. Sekv. (protein)NP_001191676NP_035388
Lokacija (UCSC)Chr 4:
39.29 - 39.37 Mb
Chr 5:
65.26 - 65.34 Mb
PubMed pretraga[1][2]

Replikacioni faktor C, podjednica 1 je protein koji je kod ljudi kodiran RFC1 genom.[1][2]

Protein kodiran ovim genom je velika podjedinica replikacionog faktora C, koji je pomoćni protein DNK polimeraze sa pet podjedinica. Replikacioni faktor C je od DNK zavisna ATPaza koja je neophodna za eukariotsku DNK replikaciju i popravku. Protein deluje kao aktivator DNK polimeraza, putem vezivanja za 3' kraj prajmera, i promoviše koordiniranu sintezu oba lanca. On takođe doprinosi stabilnosti telomera.[2]

Interakcije[uredi - уреди | uredi izvor]

RFC1 formira interakcije sa BRD4,[3] HDAC1,[4] RFC3,[5][6][7] RELA[8] i PCNA.[3][9][10][11][12]

Reference[uredi - уреди | uredi izvor]

  1. Luckow B, Bunz F, Stillman B, Lichter P, Schutz G (Mar 1994). "Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans". Mol Cell Biol 14 (3): 1626–34. PMC 358521. PMID 8114700.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5981. 
  3. 3,0 3,1 Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). "A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase". Mol. Cell. Biol. (United States) 22 (18): 6509–20. ISSN 0270-7306. PMC 135621. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.  Check date values in: |date= (help)
  4. Anderson, Lisa A; Perkins Neil D (Aug 2002). "The large subunit of replication factor C interacts with the histone deacetylase, HDAC1". J. Biol. Chem. (United States) 277 (33): 29550–4. ISSN 0021-9258. PMID 12045192. doi:10.1074/jbc.M200513200.  Check date values in: |date= (help)
  5. Ellison, V; Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. ISSN 0021-9258. PMID 9488738. doi:10.1074/jbc.273.10.5979.  Check date values in: |date= (help)
  6. Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). "In vitro reconstitution of human replication factor C from its five subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. ISSN 0027-8424. PMC 39056. PMID 8692848. doi:10.1073/pnas.93.13.6521.  Check date values in: |date= (help)
  7. Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr 2008). "DNA Damage-induced Ubiquitylation of RFC2 Subunit of Replication Factor C Complex". J. Biol. Chem. (United States) 283 (14): 9071–9. ISSN 0021-9258. PMC 2431014. PMID 18245774. doi:10.1074/jbc.M709835200.  Check date values in: |date= (help)
  8. Anderson, Lisa A; Perkins Neil D (Jan 2003). "Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C". Mol. Cell. Biol. (United States) 23 (2): 721–32. ISSN 0270-7306. PMC 151544. PMID 12509469. doi:10.1128/MCB.23.2.721-732.2003.  Check date values in: |date= (help)
  9. Fotedar, R; Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (Aug 1996). "A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells". EMBO J. (ENGLAND) 15 (16): 4423–33. ISSN 0261-4189. PMC 452166. PMID 8861969.  Check date values in: |date= (help)
  10. Mossi, R; Jónsson Z O, Allen B L, Hardin S H, Hübscher U (Jan 1997). "Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen". J. Biol. Chem. (UNITED STATES) 272 (3): 1769–76. ISSN 0021-9258. PMID 8999859. doi:10.1074/jbc.272.3.1769.  Check date values in: |date= (help)
  11. van der Kuip, H; Carius B, Haque S J, Williams B R, Huber C, Fischer T (Apr 1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. (GERMANY) 77 (4): 386–92. ISSN 0946-2716. PMID 10353443. doi:10.1007/s001090050365.  Check date values in: |date= (help)
  12. Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]