RFC3

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Replikacioni faktor C (aktivator 1) 3, 38kDa
Identifikatori
SimboliRFC3; RFC38
Vanjski IDOMIM600405 MGI1916513 HomoloGene2188 GeneCards: RFC3 Gene
Pregled RNK izražavanja
PBB GE RFC3 204127 at tn.png
PBB GE RFC3 204128 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez598369263
EnsemblENSG00000133119ENSMUSG00000033970
UniProtP40938Q8R323
Ref. Sekv. (iRNK)NM_002915NM_027009
Ref. Sekv. (protein)NP_002906NP_081285
Lokacija (UCSC)Chr 13:
34.39 - 34.54 Mb
Chr 5:
151.64 - 151.65 Mb
PubMed pretraga[1][2]

Replikacioni faktor C, podjedinica 3 je protein koji je kod ljudi kodiran RFC3 genom.[1][2]

Za elongaciju prajmiranog DNK šablona DNK polimerazom delta i DNK polimerazom epsilon neophodni su pomoćni proteini: proliferativni ćelijski nuklearni antigen (PCNA) i replikacioni faktor C (RFC). RFC, takođe poznat kao aktivator 1, je proteinski kompleks koji se sastoji od pet podjedinica sa 140, 40, 38, 37, i 36 kDa. Ovaj gen kodira 38 kDa podjednicu. Ta podjedinica je esencijalna za interakciju između 140 kDa podjedinice i srži kompleksa koja se sastoji od 36, 37, i 40 kDa podjedinica. Poznate su alternativno splajsovane transcriptne varijante koje kodiraju različite izoforme.[2]

Interakcije[uredi - уреди | uredi izvor]

RFC3 formira interakcije sa BRD4,[3] CHTF18,[4][5] RFC1,[6][7][8] PCNA[5][9] i RFC4.[6][7]

Reference[uredi - уреди | uredi izvor]

  1. Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K et al. (Jul 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics 25 (1): 274–8. PMID 7774928. doi:10.1016/0888-7543(95)80135-9.  Check date values in: |date= (help)
  2. 2,0 2,1 "Entrez Gene: RFC3 replication factor C (activator 1) 3, 38kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5983. 
  3. Maruyama, Tetsuo; Farina Andrea, Dey Anup, Cheong JaeHun, Bermudez Vladimir P, Tamura Tomohiko, Sciortino Selvaggia, Shuman Jon, Hurwitz Jerard, Ozato Keiko (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Mol. Cell. Biol. (United States) 22 (18): 6509–20. ISSN 0270-7306. PMC 135621. PMID 12192049. doi:10.1128/MCB.22.18.6509-6520.2002.  Check date values in: |date= (help)
  4. Bermudez, Vladimir P; Maniwa Yoshimasa, Tappin Inger, Ozato Keiko, Yokomori Kyoko, Hurwitz Jerard (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (18): 10237–42. ISSN 0027-8424. PMC 193545. PMID 12930902. doi:10.1073/pnas.1434308100.  Check date values in: |date= (help)
  5. 5,0 5,1 Merkle, Carolin J; Karnitz Larry M, Henry-Sánchez John T, Chen Junjie (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". J. Biol. Chem. (United States) 278 (32): 30051–6. ISSN 0021-9258. PMID 12766176. doi:10.1074/jbc.M211591200.  Check date values in: |date= (help)
  6. 6,0 6,1 Ellison, V; Stillman B (Mar 1998). "Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity". J. Biol. Chem. (UNITED STATES) 273 (10): 5979–87. ISSN 0021-9258. PMID 9488738. doi:10.1074/jbc.273.10.5979.  Check date values in: |date= (help)
  7. 7,0 7,1 Uhlmann, F; Cai J, Flores-Rozas H, Dean F B, Finkelstein J, O'Donnell M, Hurwitz J (Jun 1996). "In vitro reconstitution of human replication factor C from its five subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (13): 6521–6. ISSN 0027-8424. PMC 39056. PMID 8692848. doi:10.1073/pnas.93.13.6521.  Check date values in: |date= (help)
  8. Tomida, Junya; Masuda Yuji, Hiroaki Hidekazu, Ishikawa Tomoko, Song Ihnyoung, Tsurimoto Toshiki, Tateishi Satoshi, Shiomi Tadahiro, Kamei Yasuhiro, Kim Jinhyeong, Kamiya Kenji, Vaziri Cyrus, Ohmori Haruo, Todo Takeshi (Apr 2008). "DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex". J. Biol. Chem. (United States) 283 (14): 9071–9. ISSN 0021-9258. PMC 2431014. PMID 18245774. doi:10.1074/jbc.M709835200.  Check date values in: |date= (help)
  9. Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. ISSN 0021-9258. PMID 12171929. doi:10.1074/jbc.M206194200.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]