Faktor licenciranja DNK replikacije MCM2

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Komponenta 2 kompleksa minihromozomskog održavanja
Identifikatori
SimboliMCM2; BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Vanjski IDOMIM116945 MGI105380 HomoloGene3325 GeneCards: MCM2 Gene
EC broj3.6.4.12
Pregled RNK izražavanja
PBB GE MCM2 202107 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez417117216
EnsemblENSG00000073111ENSMUSG00000002870
UniProtP49736P97310
Ref. Sekv. (iRNK)NM_004526NM_008564
Ref. Sekv. (protein)NP_004517NP_032590
Lokacija (UCSC)Chr 3:
127.32 - 127.34 Mb
Chr 6:
88.88 - 88.9 Mb
PubMed pretraga[1][2]

Faktor licenciranja DNK replikacije MCM2 je protein koji je kod ljudi kodiran MCM2 genom.[1][2]

Protein kodiran ovim genom je jedan od visoko konzerviranjih proteina održavanja mini-hromozoma (MCM) koji učestvuju u inicijaciji replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prereplikacionog kompleksa (pre-RC). On učestuje u formiranju replikacionih viljuški i regrutaciji drugih srodnih proteina replikacije DNK. Ovaj protein formira kompleks sa MCM4, 6, i 7, i pokazano je da reguliše helikaznu aktivnost kompleksa. Ovaj protein fosforilišu, i tim putem regulišu, proteinske kinaze CDC2 i CDC7.[3]

Interakcije[uredi - уреди | uredi izvor]

MCM2 formira interakcije sa replikacionim proteinom A1,[4] AKAP8,[5] MCM5,[4][6] MCM6,[4][7][8][9][10] MCM7,[4][8][9][10][11] ORC1L,[4] ORC2L,[4] ORC4L,[4] ORC5L,[4] MCM4,[4][8][9][12] MCM3[4] i proteinska kinaza srodna sa kinazom ciklusa ćelijske deobe 7.[4]

Reference[uredi - уреди | uredi izvor]

  1. Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun 177 (1): 395–400. PMID 1710453. doi:10.1016/0006-291X(91)91996-P.  Check date values in: |date= (help)
  2. Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet 65 (4): 276–7. PMID 8258304. doi:10.1159/000133647.  Check date values in: |date= (help)
  3. "Entrez Gene: MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4171. 
  4. 4,00 4,01 4,02 4,03 4,04 4,05 4,06 4,07 4,08 4,09 4,10 Kneissl Margot, Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2.  Check date values in: |date= (help)
  5. Eide Turid, Taskén Kristin A, Carlson Cathrine, Williams Gareth, Jahnsen Tore, Taskén Kjetil, Collas Philippe (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. (United States) 278 (29): 26750–6. ISSN 0021-9258. PMID 12740381. doi:10.1074/jbc.M300765200.  Check date values in: |date= (help)
  6. DaFonseca C J, Shu F, Zhang J J (Mar 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. ISSN 0027-8424. PMC 30602. PMID 11248027. doi:10.1073/pnas.061487598.  Check date values in: |date= (help)
  7. Rual Jean-François, Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.  Check date values in: |date= (help)
  8. 8,0 8,1 8,2 Yabuta Norikazu, Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells (England) 8 (5): 413–21. ISSN 1356-9597. PMID 12694531. doi:10.1046/j.1365-2443.2003.00645.x. 
  9. 9,0 9,1 9,2 You Z, Komamura Y, Ishimi Y (Dec 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526.  Check date values in: |date= (help)
  10. 10,0 10,1 You Zhiying, Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. (United States) 277 (45): 42471–9. ISSN 0021-9258. PMID 12207017. doi:10.1074/jbc.M205769200.  Check date values in: |date= (help)
  11. Fujita M, Kiyono T, Hayashi Y, Ishibashi M (Apr 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. ISSN 0021-9258. PMID 9099751. doi:10.1074/jbc.272.16.10928.  Check date values in: |date= (help)
  12. Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (Sep 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. ISSN 0021-9258. PMID 8798650. doi:10.1074/jbc.271.39.24115.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]