SKF-83959

Izvor: Wikipedia
SKF-83959
(IUPAC) ime
6-hloro-7,8-dihidroksi-3-metil-1-(3-metilfenil)-2,3,4,5-tetrahidro-1H-3-benzazepin
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 24278699
ChemSpider[3] 10131933
ChEMBL[4] CHEMBL520992 YesY
Hemijski podaci
Formula C18H20ClNO2 
Mol. masa 317,810 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

SKF-83,959 je sintetički benzazepinski derivat koji se koristi u naučnim istraživanjima. On deluje kao selektivni antagonist D1 receptor i pun agonist D5 receptora. On ima visok afinitet za oba receptora, te stimuliše putem D5 receptora PLC/PI put sekundarnog glasnika bez uticaja na cAMP/AC put, koji je povezan sa D1 receptorom.[5][6][7][8]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Jin LQ, Goswami S, Cai G, Zhen X, Friedman E (April 2003). "SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain". Journal of Neurochemistry 85 (2): 378–86. PMID 12675914. 
  6. Zhen X, Goswami S, Friedman E (April 2005). "The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959". Pharmacology, Biochemistry, and Behavior 80 (4): 597–601. doi:10.1016/j.pbb.2005.01.016. PMID 15820529. 
  7. Zhang ZJ, Jiang XL, Zhang SE, Hough CJ, Li H, Chen JG, Zhen XC (2005). "The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm". Neuroscience Letters 382 (1-2): 134–8. doi:10.1016/j.neulet.2005.03.001. PMID 15911136. 
  8. Sahu A, Tyeryar KR, Vongtau HO, Sibley DR, Undieh AS (March 2009). "D5 dopamine receptors are required for dopaminergic activation of phospholipase C". Molecular Pharmacology 75 (3): 447–53. doi:10.1124/mol.108.053017. PMID 19047479. 

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