Hinpirol

Hinpirol
	(4aR,8aR)-5-propil-4,4a,5,6,7,8,8a,9-oktahidro-1H-pirazolo[3,4-g]hinolin
Identifikacija
CAS registarski broj	80373-22-4
PubChem	54562
ChEMBL	CHEMBL240773
IUPHAR ligand	2
Jmol-3D slike	Slika 1
SMILES
	CCCN1CCC[C@H]2[C@H]1CC3=C(C2)NN=C3
InChI
	InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1 ; Kod: FTSUPYGMFAPCFZ-ZWNOBZJWSA-N
Svojstva
Molekulska formula	C13H21N3
Molarna masa	219.33 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Hinpirol je psihoaktivni lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni agonist D₂ i D₃ receptora.^[4]^[5]^[6] Za hinpirol je pokazano da povećava lokomotornu aktivnost kod miševa. U jednoj studiji je nađeno da on indukuje kompulzivno ponašanje koje je simptomatično za opsesivno-kompulzivni poremećaj kod pacova.^[7]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Eilam D, Szechtman H (February 1989). „Biphasic effect of D-2 agonist quinpirole on locomotion and movements”. European Journal of Pharmacology 161 (2–3): 151–7. DOI:10.1016/0014-2999(89)90837-6. PMID 2566488.
↑ Navarro JF, Maldonado E (September 1999). „Behavioral profile of quinpirole in agonistic encounters between male mice”. Methods and Findings in Experimental and Clinical Pharmacology 21 (7): 477–80. PMID 10544391.
↑ Culm KE, Lugo-Escobar N, Hope BT, Hammer RP (October 2004). „Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats”. Neuropsychopharmacology 29 (10): 1823–30. DOI:10.1038/sj.npp.1300483. PMID 15138441.
↑ Szechtman Henry, Sulis William, Eilam David (1998). „Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)”. Behavioral Neuroscience 112 (6): 1475–85. DOI:10.1037/0735-7044.112.6.1475. PMID 9926830.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid2566488-4] Eilam D, Szechtman H (February 1989). „Biphasic effect of D-2 agonist quinpirole on locomotion and movements”. European Journal of Pharmacology 161 (2–3): 151–7. DOI:10.1016/0014-2999(89)90837-6. PMID 2566488.

[pmid10544391-5] Navarro JF, Maldonado E (September 1999). „Behavioral profile of quinpirole in agonistic encounters between male mice”. Methods and Findings in Experimental and Clinical Pharmacology 21 (7): 477–80. PMID 10544391.

[pmid15138441-6] Culm KE, Lugo-Escobar N, Hope BT, Hammer RP (October 2004). „Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats”. Neuropsychopharmacology 29 (10): 1823–30. DOI:10.1038/sj.npp.1300483. PMID 15138441.

[7] Szechtman Henry, Sulis William, Eilam David (1998). „Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)”. Behavioral Neuroscience 112 (6): 1475–85. DOI:10.1037/0735-7044.112.6.1475. PMID 9926830.

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Hinpirol

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