Inhibitor timidilatne sintaze

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Inhibitori timidilatne sintaze su hemijski agensi koji inhibiraju enzim timidilatna sintaza, te mogu da nađu primenu u antikancernoj hemoterapiji.[1] Pet agenasa je bilo u kliničkim israživanjima 2002: raltitreksed, pemetreksed, nolatreksed, ZD9331, i GS7904L.[2]

Primeri lekova ove klase su:

Reference[uredi - уреди | uredi izvor]

  1. Jackman, A.L.; Calvert, A.H. (1995). "Folate-based thymidylate synthase inhibitors as anticancer drugs". Annals of Oncology 6 (9): 871–881. 
  2. "Thymidylate synthase inhibitors as anticancer agents: from bench to bedside". http://cat.inist.fr/?aModele=afficheN&cpsidt=15072905+. pristupljeno 2009-01-28. 
  3. Papamichael, D. (1999). "The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status". Oncologist 4 (6): 478–87. PMID 10631692. 
  4. Gibbs, David D. et al. (2005). "BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to α-folate receptor-overexpressing tumors". Cancer Research 65 (24): 11721–11728. doi:10.1158/0008-5472.CAN-05-2034. 
  5. Ricart AD, Berlin JD, Papadopoulos KP et al. (December 2008). "Phase I, pharmacokinetic and biological correlative study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor, and cisplatin in patients with solid tumors". Clin. Cancer Res. 14 (23): 7947–55. PMID 19047127. doi:10.1158/1078-0432.CCR-08-0864.