Timidilatna sintaza

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Timidilat sintaza
5x5d.jpg
Timidilat sintaza dimer, Human
Identifikatori
EC broj 2.1.1.45
CAS broj 9031-61-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Timidilat sintaza (EC 2.1.1.45, dTMP sintaza, timidilatna sintetaza, metilintetrahidrofolat:dUMP C-metiltransferaza, TMP sintetaza) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat:dUMP C-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

5,10-metilintetrahidrofolat + dUMP dihidrofolat + dTMP

Reference[uredi - уреди | uredi kôd]

  1. Blakley, R.L. (1963). „The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase”. J. Biol. Chem. 238: 2113-2118. 
  2. Lockshin, A., Moran, R.G. and Danenberg, P.V. (1979). „Thymidylate synthetase purified to homogeneity from human leukemic cells”. Proc. Natl. Acad. Sci. USA 76: 750-754. PMID 34155. 
  3. Slavik, K. and Slavikova, V. (1980). „Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography”. Methods Enzymol. 66: 709-723. PMID 6990200. 
  4. Wahba, A.J. and Friedkin, M. (1962). „The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli”. J. Biol. Chem. 237: 3794-3801. PMID 13998281. 

Literatura[uredi - уреди | uredi kôd]

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