Karmustin

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Karmustin
Skeletal formula of carmustine
Ball-and-stick model of carmustine molecule
IUPAC ime
Drugi nazivi N,N’-Bis(2-hloroetil)-N-nitrozo-ureja
Identifikacija
CAS registarski broj 154-93-8 YesY
PubChem[2][3] 2578
ChemSpider[4] 2480 YesY
UNII U68WG3173Y YesY
EINECS broj 205-838-2
UN broj 2811
DrugBank DB00262
KEGG[5] D00254
MeSH Carmustine
ChEBI 3423
ChEMBL[6] CHEMBL513 YesY
RTECS registarski broj toksičnosti YS2625000
ATC code L01AD01
Jmol-3D slike
Svojstva
Molekulska formula C5H9Cl2N3O2
Molarna masa 214.05 g mol−1
Agregatno stanje Orange crystals-lat
Miris Bez mirisa
Tačka topljenja

30 °C, 303 K, 86 °F

log P 1,375
pKa 10,194
Baznost (pKb) 3,803
Farmakologija
Bioraspoloživost 5–28%
Načini upotrebe Intravenozno
Metabolizam Hepatički
Vreme polu-uklanjanja iz organizma 15–30 min
Proteinsko vezivanje 80%
Ekskrecija
  • Renalno
  • Respiratorno
Legalni status


Prescription only

Opasnost
EU-klasifikacija Very Toxic T+
R-oznake R45, R46, R60, R61, R28
S-oznake S22, S36/37/39, S45
LD50 20 mg kg−1 (oralno, pacov)
Srodna jedinjenja
Srodna ureje Dimetilureja
Srodna jedinjenja

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Karmustin ili BCNU (bis-hloroetilnitrozoureja) je β-hloro-nitrozourejno jedinjenje strodno sa azotnim iperitom, koje se koristi kao alkilirajući agens u hemoterapiji.[7][8] Kao dialkilirajući agens, BCNU ima sposobnost formiranja veza između DNK lanaca, čime se onemogućava DNK replikacija i DNK transkripcija.

It has the appearance of an orange-yellow solid.

Carmustine for injection is marketed under the name BiCNU by Bristol-Myers Squibb. In India, carmustine is marketed under the name Carustine by Curacell Biotech.

Reference[uredi - уреди | uredi izvor]

  1. "Carmustine - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identification. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2578#x291. pristupljeno 11. 4. 2012.. 
  2. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  3. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  4. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  5. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  6. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  7. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  8. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets" 36 (Database issue). pp. D901–6. PMID 18048412. 

Spoljašnje veze[uredi - уреди | uredi izvor]

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