RGS10

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Regulator G-proteinske signalizacije 10
PDB prikaz baziran na 2dlr.
Dostupne strukture
2DLR, 2I59, 2IHB
Identifikatori
Simbol	RGS10
Vanjski ID	OMIM: 602856 MGI: 1915115 HomoloGene: 37710 GeneCards: RGS10 Gene
Ontologija gena Molekulska funkcija • aktivnost GTPaznog aktivatora Ćelijska komponenta • nukleus • nukleolus • citoplazma Biološki proces • terminacija signalnog puta G-protein spregnutog receptora • pozitivna regulacija GTPazne aktivnosti
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6001	67865
Ensembl	ENSG00000148908	ENSMUSG00000030844
UniProt	O43665	Q9CQE5
Ref. Sekv. (iRNK)	NM_001005339	NM_026418
Ref. Sekv. (protein)	NP_001005339	NP_080694
Lokacija (UCSC)	Chr 10: 121.26 - 121.3 Mb	Chr 7: 128.37 - 128.42 Mb
PubMed pretraga	[1]	[2]

Regulator G-proteinske signalizacije 10 je protein koji je kod ljudi kodiran RGS10 genom.

Članovi familje regulatora G proteinske signalizacije (RGS) su regulatorni molekuli koji deluju kao aktivirajući proteini GTPaze (GAP) za G alfa podjedinice heterotrimernih G proteina. RGS proteini imaju sposobnost deaktivacije G proteinskih podjedinica Gi alfa, Go alfa i Gq alfa podtipova. Oni dovode G proteine u njihove neaktivne, GDP-vezane forme. Regulator G proteinske signalizacije 10 pripada toj familiji. Svi RGS proteini imaju zajedničku, konzerviranu 120-aminokiselina dugu sekvencu koja se naziva RGS domen. Ovaj protein se specifično vezuje za aktivirane forme dve srodne G-proteinske podjedinice, G-alfai3 i G-alfaz, i ne formira interakcije sa strukturno i funkcionalno različitim G-alfa podjednicama. Regulator G proteinske signalizacije je lociran u jedru. Njegove dve transkriptne varijante kodiraju različiti izoforme.

Interakcije

Poznato je da RGS10 formira interakcije sa SAP18 i GNAI3.

Literatura

• Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216–20. DOI:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071. //www.ncbi.nlm.nih.gov/pmc/articles/PMC23796/. 
• Tu Y, Wang J, Ross EM (1997). "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.". Science 278 (5340): 1132–5. DOI:10.1126/science.278.5340.1132. PMID 9353196. 
• Tu Y, Popov S, Slaughter C, Ross EM (2000). "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.". J. Biol. Chem. 274 (53): 38260–7. DOI:10.1074/jbc.274.53.38260. PMID 10608901. 
• Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. DOI:10.1074/jbc.M001128200. PMID 10747990. 
• Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.". J. Biol. Chem. 275 (31): 24013–21. DOI:10.1074/jbc.M002082200. PMID 10791963. 
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• Castro-Fernández C, Conn PM (2003). "Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus.". Mol. Cell. Endocrinol. 191 (2): 149–56. DOI:10.1016/S0303-7207(02)00082-5. PMID 12062898. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. DOI:10.1007/s00335-005-0075-2. PMID 16341674. 
• Lee HK, Rhee KH, Kim CW, et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 9): 831–3. DOI:10.1107/S1744309105023602. PMC 1978115. PMID 16511171. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1978115/. 
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