Glukoza-6-fosfat dehidrogenaza (koenzim-F420)
(Preusmjereno sa stranice FGD1)
| Glukoza-6-fosfat dehidrogenaza (koenzim-F420) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.98.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glukoza-6-fosfat dehidrogenaza (koenzim-F420) (EC 1.1.98.2, koenzim F420-zavisna glukoza-6-fosfatna dehidrogenaza, F420-zavisna glukoza-6-fosfatna dehidrogenaza, FGD1, Rv0407, F420-zavisna glukoza-6-fosfatna dehidrogenaza 1) je enzim sa sistematskim imenom D-glukoza-6-fosfat:F420 1-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- D-glukoza 6-fosfat + oksidovani koenzim F420 6-fosfo-D-glukono-1,5-lakton + redukovani koenzim F420
Ovaj enzim je veoma specifičan za D-glukoza 6-fosfat. Nije aktivan sa NAD+, NADP+, flavin adenin dinukleotidom I flavin mononukleotidom.
Reference[uredi | uredi kod]
- ↑ Purwantini, E. and Daniels, L. (1996). „Purification of a novel coenzyme F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis”. J. Bacteriol. 178: 2861-2866. PMID 8631674.
- ↑ Bashiri, G., Squire, C.J., Baker, E.N. and Moreland, N.J. (2007). „Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system”. Protein Expr. Purif. 54: 38-44. PMID 17376702.
- ↑ Purwantini, E., Gillis, T.P. and Daniels, L. (1997). „Presence of F420-dependent glucose-6-phosphate dehydrogenase in Mycobacterium and Nocardia species, but absence from Streptomyces and Corynebacterium species and methanogenic Archaea”. FEMS Microbiol. Lett. 146: 129-134. PMID 8997717.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.