RGS20

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Regulator G-proteinske signalizacije 20
Identifikatori
SimboliRGS20; RGSZ1; ZGAP1; g(z)GAP; gz-GAP
Vanjski IDOMIM607193 MGI1929866 HomoloGene2745 GeneCards: RGS20 Gene
Pregled RNK izražavanja
PBB GE RGS20 210138 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez860158175
EnsemblENSG00000147509ENSMUSG00000002459
UniProtO76081Q9QZB1
Ref. Sekv. (iRNK)NM_001286673NM_001177795
Ref. Sekv. (protein)NP_001273602NP_001171266
Lokacija (UCSC)Chr 8:
54.76 - 54.87 Mb
Chr 1:
4.91 - 5.07 Mb
PubMed pretraga[1][2]

Regulator G-proteinske signalizacije 20 je protein koji je kod ljudi kodiran RGS20 genom.[1][2][3]

Regulatori G proteinske signalizacije (RGS) su regulatorne i strukturne komponente G protein-spregnutih receptorskih kompleksa. RGS proteini su GTPazni aktivatori za Gi (GNAI1; MIM 139310) i Gq (GNAQ; MIM 600998) klasu G-alfa proteina. Oni ubrzavaju tranzit kroz ciklus GTP vezivanja i hidrolize i tim putem ubrzavaju signalizacionu kinetiku i terminaciju.[3]

Interakcije[uredi - уреди | uredi izvor]

RGS20 formira interakcije sa GNAO1[4] i GNAZ.[1][5]

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J Biol Chem 273 (40): 26008–13. PMID 9748279. doi:10.1074/jbc.273.40.26008.  Check date values in: |date= (help) Greška kod citiranja: Nevaljana oznaka <ref>; naziv "pmid9748279" je zadan više puta s različitim sadržajem
  2. Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J Biol Chem 273 (40): 26014–25. PMID 9748280. doi:10.1074/jbc.273.40.26014.  Check date values in: |date= (help)
  3. 3,0 3,1 "Entrez Gene: RGS20 regulator of G-protein signalling 20". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8601. 
  4. Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. (England) 20 (6): 1190–7. ISSN 0898-6568. PMC 3107604. PMID 18407463. doi:10.1016/j.cellsig.2008.02.008.  Check date values in: |date= (help)
  5. Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell. Sci. (England) 115 (Pt 23): 4483–93. ISSN 0021-9533. PMID 12414994. doi:10.1242/jcs.00093.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]