RGS7

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Regulator G-proteinske signalizacije 7

PDB prikaz baziran na 2a72.
Dostupne strukture
2A72, 2D9J
Identifikatori
SimbolRGS7
Vanjski IDOMIM602517 MGI1346089 HomoloGene2193 GeneCards: RGS7 Gene
Pregled RNK izražavanja
PBB GE RGS7 206290 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez600024012
EnsemblENSG00000182901ENSMUSG00000026527
UniProtP49802O54829
Ref. Sekv. (iRNK)NM_001282773NM_001199003
Ref. Sekv. (protein)NP_001269702NP_001185932
Lokacija (UCSC)Chr 1:
240.93 - 241.52 Mb
Chr 1:
175.06 - 175.49 Mb
PubMed pretraga[1][2]

Regulator G-proteinske signalizacije 7 je protein koji je kod ljudi kodiran RGS7 genom.[1][2]

RGS7 se nalazi u povišenoj koncentraciji u mozgu, gde deluje kao universalni inhibitor Gi/o-spregnutih GPCR. RGS7 je aktivirajući protein GTPaze (GAP). On ubrzava GTP hidrolizu na G proteinima, čime određuje njihovu brzu inaktivaciju. Isto tako deluje kao intraćeliski antagonist GPCR signalizacije.[3]

Interacije[uredi - уреди | uredi izvor]

Pokazano je da RGS7 formira interakcije sa GPR158,[4] PKD1,[5] GNB5[6][7] i SNAPAP.[8]

Reference[uredi - уреди | uredi izvor]

  1. Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell 84 (1): 115–25. PMID 8548815. doi:10.1016/S0092-8674(00)80998-8.  Check date values in: |date= (help)
  2. "Entrez Gene: RGS7 regulator of G-protein signalling 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6000. 
  3. Anderson, Garret R.; Ekaterina Posokhova; Kirill A. Martemyanov (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics 54 (1-3): 33-46. PMID 19521673. doi:10.1007/s12013-009-9052-9. 
  4. Orlandi, Cesare; Ekaterina Posokhova; Ikuo Masuho; Thomas A. Ray; Nazarul Hasan; Ronald G. Gregg; Kirill A. Martemyanov (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". Journal of Cell Biology 197 (6): 711-719. PMID 22689652. doi:10.1083/jcb.201202123. 
  5. Kim, E; Arnould T; Sellin L; Benzing T; Comella N; Kocher O; Tsiokas L; Sukhatme V P; Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (11): 6371–6. ISSN 0027-8424. PMC 26888. PMID 10339594. doi:10.1073/pnas.96.11.6371. 
  6. Levay, K; Cabrera J L; Satpaev D K; Slepak V Z (Mar 1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (5): 2503–7. ISSN 0027-8424. PMC 26814. PMID 10051672. doi:10.1073/pnas.96.5.2503.  Check date values in: |date= (help)
  7. Posner, B A; Gilman A G; Harris B A (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. (UNITED STATES) 274 (43): 31087–93. ISSN 0021-9258. PMID 10521509. doi:10.1074/jbc.274.43.31087.  Check date values in: |date= (help)
  8. Hunt, Rachel A; Edris Wade; Chanda Pranab K; Nieuwenhuijsen Bart; Young Kathleen H (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. (United States) 303 (2): 594–9. ISSN 0006-291X. PMID 12659861. doi:10.1016/S0006-291X(03)00400-5.  Check date values in: |date= (help)

Literatura[uredi - уреди | uredi izvor]