RGS8

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Regulator G-proteinske signalizacije 8
PDB prikaz baziran na 2ihd.
Dostupne strukture
2IHD, 2ODE
Identifikatori
Simboli	RGS8; MGC119067; MGC119068; MGC119069
Vanjski ID	OMIM: 607189 HomoloGene: 23152 GeneCards: RGS8 Gene
Ontologija gena Molekulska funkcija • aktivnost GTPaznog aktivatora Ćelijska komponenta • citoplazma • ćelijska membrana Biološki proces • terminacija signalnog puta G-protein spregnutog receptora • pozitivna regulacija GTPazne aktivnosti
Ortolozi
Vrsta	Čovek	Miš
Entrez	85397	67792
Ensembl	ENSG00000135824	ENSMUSG00000042671
UniProt	P57771	Q8BXT1
Ref. Sekv. (iRNK)	NM_001102450	NM_026380
Ref. Sekv. (protein)	NP_001095920	NP_080656
Lokacija (UCSC)	Chr 1: 182.62 - 182.65 Mb	Chr 1: 153.65 - 153.7 Mb
PubMed pretraga	[1]	[2]

Regulator G-proteinske signalizacije 8 je protein koji je kod ljudi kodiran RGS8 genom.

Ovaj gen je član familje regulatora G proteinske signalizacije (RGS). On kodira protein sa jednim RGS domenom. Regulatori G proteinske signalizacije (RGS) su regulatorne i strukturne komponente G protein spregnutih receptorskih kompleksa. Oni ubrzavaju prenos kroz ciklus GTP vezivanja i hidrolize do GDP, čime završavaju prenos signala, mada paradoksalno, isto tako ubrzavaju receptorom stimulisanu aktivaciju.

Literatura

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• Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (2011). „Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner”. J Biol Chem 286 (17): 15116-15125. DOI:10.1074/jbc.M110.216234. PMID 21357625. 
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