RGS4

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Regulator G-proteinske signalizacije 4

PDB rendering based on 1agr.
Dostupne strukture
1agr, 1ezt, 1ezy
Identifikatori
SimboliRGS4; MGC2124; MGC60244; RGP4; SCZD9
Vanjski IDOMIM602516 MGI108409 HomoloGene4100 GeneCards: RGS4 Gene
Pregled RNK izražavanja
PBB GE RGS4 204337 at tn.png
PBB GE RGS4 204338 s at tn.png
PBB GE RGS4 204339 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez599919736
EnsemblENSG00000117152ENSMUSG00000038530
UniProtP49798Q5D078
RefSeq (mRNA)NM_005613NM_009062
RefSeq (protein)NP_005604NP_033088
Lokacija (UCSC)Chr 1:
161.31 - 161.31 Mb
Chr 1:
171.58 - 171.58 Mb
PubMed pretraga[1][2]

Regulator G proteinske signalizacije 4 (RGS4) je protein koji reguliše G proteinsku signalizaciju.[1] Brojne sudije su ukazale na vezu RGS4 gena sa šizofrenijom,[2][3][4][5] mada postoje i studije koje nisu ustanovile vezu.[6]

RGS4 je takođe od interesa kao jedan od tri glavna RGS proteina (zajedno sa RGS9 i RGS17) koji učestvuju u terminaciji signalizacije mi opioidnog receptora,[7] i moguće je da je značajan u razvoju tolerancije na opioidne lekove.[8][9][10][11][12]

Inhibitori[uredi - уреди | uredi izvor]

Interakcije[uredi - уреди | uredi izvor]

Za RGS4 je pokazano da interaguje sa ERBB3,[15] GNAQ[16] i COPB2.[17]

Reference[uredi - уреди | uredi izvor]

  1. "Entrez Gene: RGS4 regulator of G-protein signalling 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5999. 
  2. Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE, Hatzimanolis A, Ioannidis JP, Stefanis CN (2008). "Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level". Behavioral and Brain Functions 4: 46. PMC 2572614. PMID 18834502. doi:10.1186/1744-9081-4-46. 
  3. Prasad KM, Almasy L, Gur RC, Gur RE, Pogue-Geile M, Chowdari KV, Talkowski ME, Nimgaonkar VL (March 2009). "RGS4 Polymorphisms Associated With Variability of Cognitive Performance in a Family-Based Schizophrenia Sample". Schizophrenia Bulletin 36 (5): 983–90. PMC 2930339. PMID 19282471. doi:10.1093/schbul/sbp002. 
  4. Dean B, Boer S, Gibbons A, Money T, Scarr E (March 2009). "Recent advances in postmortem pathology and neurochemistry in schizophrenia". Current Opinion in Psychiatry 22 (2): 154–60. PMID 19553869. doi:10.1097/YCO.0b013e328323d52e. 
  5. Ding L, Hegde AN (March 2009). "Expression of RGS4 splice variants in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients". Biological Psychiatry 65 (6): 541–5. PMID 19041089. doi:10.1016/j.biopsych.2008.10.026. 
  6. Stuart Gibbons A, Scarr E, McOmish CE, Hannan AJ, Thomas EA, Dean B (August 2008). "Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia". The Australian and New Zealand Journal of Psychiatry 42 (8): 740–5. PMID 18622782. doi:10.1080/00048670802206338. 
  7. Hooks SB, Martemyanov K, Zachariou V (January 2008). "A role of RGS proteins in drug addiction". Biochemical Pharmacology 75 (1): 76–84. PMID 17880927. doi:10.1016/j.bcp.2007.07.045. 
  8. Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF (May 2005). "Generation and characterization of Rgs4 mutant mice". Molecular and Cellular Biology 25 (10): 4221–8. PMC 1087729. PMID 15870291. doi:10.1128/MCB.25.10.4221-4228.2005. 
  9. Garzón J, Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P (June 2005). "Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS". Psychopharmacology 180 (1): 1–11. PMID 15830230. doi:10.1007/s00213-005-2248-9. 
  10. Georgoussi Z, Leontiadis L, Mazarakou G, Merkouris M, Hyde K, Hamm H (June 2006). "Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling". Cellular Signalling 18 (6): 771–82. PMID 16120478. doi:10.1016/j.cellsig.2005.07.003. 
  11. Leontiadis LJ, Papakonstantinou MP, Georgoussi Z (July 2009). "Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling". Cellular Signalling 21 (7): 1218–28. PMID 19324084. doi:10.1016/j.cellsig.2009.03.013. 
  12. Wang Q, Liu-Chen LY, Traynor JR (July 2009). "Differential Modulation of {micro and {deltaOpioid Receptor Agonists by Endogenous RGS4 Protein in SH-SY5Y Cells". The Journal of Biological Chemistry 284 (27): 18357–67. PMID 19416973. doi:10.1074/jbc.M109.015453. 
  13. Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI (2004). "Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity". Methods in Enzymology 389: 266–77. PMID 15313571. doi:10.1016/S0076-6879(04)89016-5. 
  14. Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR (January 2007). "Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay". Molecular Pharmacology 71 (1): 169–75. PMID 17012620. doi:10.1124/mol.106.028670. 
  15. Thaminy, Safia; Auerbach Daniel, Arnoldo Anthony, Stagljar Igor (July 2003). "Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system". Genome Res. (United States) 13 (7): 1744–53. ISSN 1088-9051. PMC 403748. PMID 12840049. doi:10.1101/gr.1276503. 
  16. Druey, K M; Sullivan B M, Brown D, Fischer E R, Watson N, Blumer K J, Gerfen C R, Scheschonka A, Kehrl J H (July 1998). "Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane". J. Biol. Chem. (UNITED STATES) 273 (29): 18405–10. ISSN 0021-9258. PMID 9660808. doi:10.1074/jbc.273.29.18405. 
  17. Sullivan, B M; Harrison-Lavoie K J, Marshansky V, Lin H Y, Kehrl J H, Ausiello D A, Brown D, Druey K M (September 2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport". Mol. Biol. Cell (UNITED STATES) 11 (9): 3155–68. ISSN 1059-1524. PMC 14982. PMID 10982407. 

Literatura[uredi - уреди | uredi izvor]