RGS2

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Regulator G-proteinske signalizacije 2

PDB prikaz baziran na 2af0.
Dostupne strukture
2AF0, 2V4Z, 4EKC, 4EKD
Identifikatori
SimboliRGS2; G0S8
Vanjski IDOMIM600861 MGI1098271 HomoloGene2192 GeneCards: RGS2 Gene
Pregled RNK izražavanja
PBB GE RGS2 202388 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez599719735
EnsemblENSG00000116741ENSMUSG00000026360
UniProtP41220O08849
Ref. Sekv. (iRNK)NM_002923NM_009061
Ref. Sekv. (protein)NP_002914NP_033087
Lokacija (UCSC)Chr 1:
192.78 - 192.78 Mb
Chr 1:
144 - 144 Mb
PubMed pretraga[1][2]

Regulator G-proteinske signalizacije 2 je protein koji je kod ljudi kodiran RGS2 genom.[1][2] On je deo velike familije RGS proteina koji kontrolišu signalizaciju putem G-protein spregnutih receptora (GPCR).

Interakcije[uredi - уреди | uredi izvor]

RGS2 formira interakcije sa PRKG1[3] and ADCY5.[4]

Reference[uredi - уреди | uredi izvor]

  1. Siderovski DP, Heximer SP, Forsdyke DR (Jun 1994). "A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells". DNA Cell Biol 13 (2): 125–47. PMID 8179820. doi:10.1089/dna.1994.13.125.  Check date values in: |date= (help)
  2. "RGS2 regulator of G-protein signaling 2, 24kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5997. 
  3. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (December 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nat. Med. 9 (12): 1506–12. PMID 14608379. doi:10.1038/nm958. 
  4. Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. PMID 12604604. doi:10.1074/jbc.M210663200. 

Literatura[uredi - уреди | uredi izvor]