RGS16

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Regulator G-protein signalizacije 16

PDB prikaz baziran na 2ik8.
Dostupne strukture
2BT2, 2IK8
Identifikatori
SimboliRGS16; A28-RGS14; A28-RGS14P; RGS-R
Vanjski IDOMIM602514 MGI108407 HomoloGene2196 GeneCards: RGS16 Gene
Pregled RNK izražavanja
PBB GE RGS16 209324 s at tn.png
PBB GE RGS16 209325 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez600419734
EnsemblENSG00000143333ENSMUSG00000026475
UniProtO15492P97428
Ref. Sekv. (iRNK)NM_002928NM_011267
Ref. Sekv. (protein)NP_002919NP_035397
Lokacija (UCSC)Chr 1:
182.57 - 182.57 Mb
Chr 1:
153.74 - 153.75 Mb
PubMed pretraga[1][2]

Regulator G-proteinske signalizacije 16 je protein koji je kod ljudi kodiran RGS16 genom.[1][2]

Protein kodiran ovim genom pripada familiji regulatora G proteinske signalizacije. On inhibira prenos signala putem povećanja GTPazne aktivnosti G proteinskih alfa podjedinica. Smatra se da on takođe učestvuje u regulaciji kinetike signalizacije fototransdukcijske kaskade.[2]

Interakcija[uredi - уреди | uredi izvor]

RGS16 formira interakcije sa GNAQ[3] i GNAI3.[4][5]

Reference[uredi - уреди | uredi izvor]

  1. Snow BE, Antonio L, Suggs S, Siderovski DP (March 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene 206 (2): 247–53. PMID 9469939. doi:10.1016/S0378-1119(97)00593-3. 
  2. 2,0 2,1 "Entrez Gene: RGS16 regulator of G-protein signalling 16". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6004. 
  3. Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis.". Nat Cell Biol 5 (12): 1095–103. PMID 14634662. doi:10.1038/ncb1065. 
  4. Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679. 
  5. Beadling, C; Druey K M; Richter G; Kehrl J H; Smith K A (March 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". J. Immunol. (UNITED STATES) 162 (5): 2677–82. ISSN 0022-1767. PMID 10072511. 

Literatura[uredi - уреди | uredi izvor]