RGS19

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Regulator G-proteinske signalizacije 19

PDB prikaz baziran na 1cmz.
Dostupne strukture
1CMZ
Identifikatori
SimboliRGS19; GAIP; RGSGAIP
Vanjski IDOMIM605071 MGI1915153 HomoloGene23320 GeneCards: RGS19 Gene
Pregled RNK izražavanja
PBB GE RGS19 204336 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez1028756470
EnsemblENSG00000171700ENSMUSG00000002458
UniProtP49795Q9CX84
Ref. Sekv. (iRNK)NM_001039467NM_001291205
Ref. Sekv. (protein)NP_001034556NP_001278134
Lokacija (UCSC)Chr 20:
62.7 - 62.71 Mb
Chr 2:
181.69 - 181.69 Mb
PubMed pretraga[1][2]

Regulator G-proteinske signalizacije 19 je protein koji je kod ljudi kodiran RGS19 genom.[1][2]

G proteini posreduju brojne ćelijske procese. Protein kodiran ovim genom pripada RGS familiji (regulatora G-proteinske signalizacije) i specifično formira interakcije sa G proteinom, GAI3. Ovaj protein je aktivirajući protein guanozin trifosfataze koji deluje putem umanjivanja Galfa i/Galfa q posredovane signalizacije.[2][3]

Interakcije[uredi - уреди | uredi izvor]

RGS19 formira interakcije sa GNAO1,[4][5] GIPC1,[6] OSTM1,[7] GNAI1,[4][5] GNAI3[1][4][5] i GNAZ.[4][8]

Reference[uredi - уреди | uredi izvor]

  1. 1,0 1,1 De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A 92 (25): 11916–20. PMC 40514. PMID 8524874. doi:10.1073/pnas.92.25.11916.  Greška kod citiranja: Nevaljana oznaka <ref>; naziv "pmid8524874" je zadan više puta s različitim sadržajem
  2. 2,0 2,1 "Entrez Gene: RGS19 regulator of G-protein signalling 19". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287. 
  3. Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell 86 (3): 445–452. PMID 8756726. doi:10.1016/S0092-8674(00)80117-8. 
  4. 4,0 4,1 4,2 4,3 De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. ISSN 0027-8424. PMC 26381. PMID 8986788. doi:10.1073/pnas.93.26.15203.  Check date values in: |date= (help)
  5. 5,0 5,1 5,2 Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718. 
  6. Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell (United States) 12 (3): 615–27. ISSN 1059-1524. PMC 30968. PMID 11251075. doi:10.1091/mbc.12.3.615. 
  7. Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (14): 8270–5. ISSN 0027-8424. PMC 166218. PMID 12826607. doi:10.1073/pnas.1432965100. 
  8. Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. ISSN 0021-9258. PMID 10906137. doi:10.1074/jbc.M004577200. 

Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]

  • RGS19 human gene location in the UCSC Genome Browser.
  • RGS19 human gene details in the UCSC Genome Browser.