Nervonska kiselina

Nervonska kiselina
	(Z)-Tetrakoz-15-enoinska kiselina
Drugi nazivi	cis-15-Tetrakozenoinska kiselina; 24:1 cis, delta 9 ili 24:1 omega 9
Identifikacija
CAS registarski broj	506-37-6
PubChem	5281120
ChemSpider	4444565
KEGG	C08323
ChEBI	44247
ChEMBL	CHEMBL1173379
Jmol-3D slike	Slika 1
SMILES
	O=C(O)CCCCCCCCCCCCC\C=C/CCCCCCCC
InChI
	InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9- ; Kod: GWHCXVQVJPWHRF-KTKRTIGZSA-N InChI=1/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9-; Kod: GWHCXVQVJPWHRF-KTKRTIGZBL
Svojstva
Molekulska formula	C24H46O2
Molarna masa	366,62 g/mol
Tačka topljenja	42–43 °C
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Nervonska kiselina je mononezasićena omega-9 masna kiselina. Utvrđeno je da je nervonska kiselina važna u biosintezi mijelina nervnih ćelija.^[7] Ona je prisutana u sfingolipidima bele materije ljudskog mozga.

Nervonska kiselina se koristi u tretmanu poremećaja uzrokovanih demijelinacijom, kao što su adrenoleukodistrofija i multipla skleroza gde postoji snižen nivo nervonske kiseline u sfingolipidima.^[8]

Reference[uredi - уреди | uredi kôd]

↑ Nervonic acid at Sigma-Aldrich
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ US Patent 6664406^{[mrtav link]}, Nervonic acid derivatives, their preparation and use
↑ WO/1996/005740, Nervonic Acid Compositions

Literatura[uredi - уреди | uredi kôd]

Appelqvist (1976) Lipids in Cruciferae. In: Vaughan JG, Macleod AJ (Eds), The biology and the Chemistry of Cruciferae. Academic Press, London, UK, pp. 221-277.
Sargent JR, Coupland K, Wilson R (1994). Nervonic Acid and Demyelinating Disease. Medical Hypothesese 42, pp. 237-242.

Spoljašnje veze[uredi - уреди | uredi kôd]

Portal Hemija

[1] Nervonic acid at Sigma-Aldrich

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[7] US Patent 6664406^{[mrtav link]}, Nervonic acid derivatives, their preparation and use

[8] WO/1996/005740, Nervonic Acid Compositions

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Nervonska kiselina

Reference[uredi - уреди | uredi kôd]

Literatura[uredi - уреди | uredi kôd]

Spoljašnje veze[uredi - уреди | uredi kôd]

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