Neklasični eikozanoid

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Neklasični eikozanoidi su biološki aktivni signalni molekuli formirani oksigenacijom masnih kiselina dugih dvadeset ugljenika koje nisu klasični eikozanoidi.

Terminologija[uredi - уреди | uredi izvor]

Eikozanoid je kolektivni[1] naziv za oksigenisane derivate tri različite esencijalne masne kiseline: eikozapentaenoinska kiselina (EPA), arahidonska kiselina (AA) i dihomo-gama-linolna kiselina (DGLA).

Sadašnja upotreba ograničava termini na leukotriene (LT) i tri tipa prostanoidaprostaglandina (PG) prostaciklina (PGI), i tromboksana (TX). Međutim, nekoliko drugih klasa se tehnički može smatrati eikozanoidima, uključujući hepoksiline, resolvine, isofurans, izoprostane, lipoksine, epilipoksine, epoksieikozatrienoinske kiseline (EET) i endokanabinoide. Leukotrieni i prostanoidi se ponekad nazivaju klasičnim eikozanoidima[2][3][4] u kontrastu sa novim, neklasičnim eikozanoidima.[5][6][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Funk, Colin D. (30 November 2001). "Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology". Science 294 (5548): 1871–1875. PMID 11729303. doi:10.1126/science.294.5548.1871. Pristupljeno 2007-01-08. 
  2. Van Dyke TE, Serhan CN (2003). "Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases". J. Dent. Res. 82 (2): 82–90. PMID 12562878. doi:10.1177/154405910308200202. 
  3. Serhan CN, Gotlinger K, Hong S, Arita M (2004). "Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis". Prostaglandins Other Lipid Mediat. 73 (3–4): 155–72. PMID 15290791. doi:10.1016/j.prostaglandins.2004.03.005. 
  4. Anderle P, Farmer P, Berger A, Roberts MA (2004). "Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acids induce gene signals and control mechanisms involved in carcinogenesis". Nutrition (Burbank, Los Angeles County, Calif.) 20 (1): 103–8. PMID 14698023. doi:10.1016/j.nut.2003.09.018. 
  5. Evans AR; Junger H; Southall MD et al. (2000). "Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons". J. Pharmacol. Exp. Ther. 293 (3): 912–20. PMID 10869392. 
  6. O'Brien WF, Krammer J, O'Leary TD, Mastrogiannis DS (1993). "The effect of acetaminophen on prostacyclin production in pregnant women". Am. J. Obstet. Gynecol. 168 (4): 1164–9. PMID 8475962. 
  7. Behrendt H, Kasche A, Ebner von Eschenbach C, Risse U, Huss-Marp J, Ring J (2001). "Secretion of proinflammatory eicosanoid-like substances precedes allergen release from pollen grains in the initiation of allergic sensitization". Int. Arch. Allergy Immunol. 124 (1–3): 121–5. PMID 11306946. doi:10.1159/000053688. 
  8. Sarau HM; Foley JJ; Schmidt DB et al. (1999). "In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity". Prostaglandins Leukot. Essent. Fatty Acids 61 (1): 55–64. PMID 10477044. doi:10.1054/plef.1999.0074. 

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