Travoprost

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Travoprost
(IUPAC) ime
propan-2-il 7-[3,5-dihidroksi-2-[3-hidroksi-4-[3-(trifluorometil)
fenoksi]-but-1-enil]-ciklopentil]hept-5-enoat
Klinički podaci
Robne marke Travatan
AHFS/Drugs.com Monografija
MedlinePlus a602027
Identifikatori
CAS broj 157283-68-6
ATC kod S01EE04
PubChem[1][2] 5282226
DrugBank DB00287
ChemSpider[3] 4445407
UNII WJ68R08KX9 YesY
KEGG[4] D01964 YesY
ChEBI CHEBI:746859 YesY
ChEMBL[5] CHEMBL1200799 YesY
Hemijski podaci
Formula C26H35F3O6 
Mol. masa 500,548 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Rx only (US)
Način primene Topikalno (kapi za oči)

Travoprost (Travatan, Travatan Z, Travo-Z) ofthalmički rastvor je topikalni lek koji se koristi za kontrolu progresije glaukoma ili okularne hipertenzije. On deluje tako što redukuje intraokularni pritisak. On je sintetički prostaglandinski analog (specifičnije, analog prostaglandina F)[6][7] koji uvećava odliv fluida iz očiju.[8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Alcon Laboratories, Inc. (September 2011). "TRAVATAN - travoprost solution". DailyMed. Bethesda, MD: U.S. National Library of Medicine. http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=338e7ff4-0d91-4208-a45d-bfa2be52334d. pristupljeno 30. 09. 2011.. 
  7. Alcon Laboratories, Inc. (September 2011). "TRAVATAN Z (travoprost) solution". DailyMed. Bethesda, MD: U.S. National Library of Medicine. http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5549684b-1724-45ca-b67b-590c62b7c149. pristupljeno 30. 09. 2011.. 
  8. AHFS Consumer Medication Information (01. 01. 2011.). "Travoprost Ophthalmic". MedlinePlus. Bethesda, MD: U.S. National Library of Medicine. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a602027.html. pristupljeno 30. 09. 2011.. 

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