Enprostil

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Enprostil
(IUPAC) ime
Metil 7-[(1S,2S,3S)- 3-hidroksi-2-[(S,E)-3-hidroksi-4-fenoksibut-1-enil]-5-oksociklopentil]hepta-4,5-dienoat
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 73121-56-9
ATC kod A02BB02
PubChem[1][2] 51744
UNII J4IP5Z9DAU YesY
KEGG[3] D01891 YesY
Hemijski podaci
Formula C23H28O6 
Mol. masa 400,46 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Enprostil je sintetički prostaglandin koji je sličan sa dinoprostonom. Enprostil je veoma potentan inhibitor sekrecije želudačne HCl.[4]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  4. Roszkowski, AP; Garay, GL; Baker, S; Schuler, M; Carter, H (1986). "Gastric antisecretory and antiulcer properties of enprostil, (+/-)-11 alpha, 15 alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-9-oxoprosta- 4,5,13(t)-trienoic acid methyl ester". The Journal of Pharmacology and Experimental Therapeutics 239 (2): 382–9. PMID 3095537. 

Literatura[uredi - уреди | uredi izvor]

  • Toshina, K.; Hirata, I.; Maemura, K.; Sasaki, S.; Murano, M.; Nitta, M.; Yamauchi, H.; Nishikawa, T.; Hamamoto, N. (2000). "Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines". Scandinavian Journal of Immunology 52 (6): 570–5. PMID 11119262. doi:10.1046/j.1365-3083.2000.00815.x. 
  • Tari, Akira; Hamada, Masanori; Kamiyasu, Toshiki; Sumii, Koji; Haruma, Ken; Inoue, Masaki; Kishimoto, Shinya; Kajiyama, Goro; Walsh, John H. (1997). "Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients". Digestive Diseases and Sciences 42 (8): 1741–6. PMID 9286243. doi:10.1023/A:1018825902055. 
  • Ching, C. K.; Lam, S. K. (1995). "A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease". Journal of Gastroenterology 30 (5): 607–14. PMID 8574332. doi:10.1007/BF02367786. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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