3',5'-Ciklični-AMP fosfodiestaraza

3',5'-Ciklični-AMP fosfodiestaraza
Identifikatori
EC broj	3.1.4.53
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	structures
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

3',5'-Ciklični-AMP fosfodiestaraza (EC 3.1.4.53, cAMP-specifična fosfodiesteraza, cAMP-specifična PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) je enzim sa sistematskim imenom 3',5'-ciklična-AMP 5'-nukleotidohidrolaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

adenozin 3',5'-ciklična fosfat + H₂O

\rightleftharpoons

AMP

Za dejstvo ovog enzim je neophodan jon Mg²⁺ ili Mn²⁺.

Reference[uredi - уреди | uredi izvor]

↑ Alonso, G.D., Schoijet, A.C., Torres, H.N. and Flawiá, M.M. (2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145: 40-49. PMID 16225937.
↑ Bader, S., Kortholt, A., Snippe, H. and Van Haastert, P.J. (2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281: 20018-20026. PMID 16644729.
↑ Rascón, A., Soderling, S.H., Schaefer, J.B. and Beavo, J.A. (2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA 99: 4714-4719. PMID 11930017.
↑ Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25-25. PMID 16522215.
↑ Lugnier, C., Keravis, T., Le Bec, A., Pauvert, O., Proteau, S. and Rousseau, E. (1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta 1472: 431-446. PMID 10564757.
↑ Imamura, R., Yamanaka, K., Ogura, T., Hiraga, S., Fujita, N., Ishihama, A. and Niki, H. (1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271: 25423-25429. PMID 8810311.

Literatura[uredi - уреди | uredi izvor]

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ.

Spoljašnje veze[uredi - уреди | uredi izvor]

MeSH 3',5'-cyclic-AMP+phosphodiesterase

[1] Alonso, G.D., Schoijet, A.C., Torres, H.N. and Flawiá, M.M. (2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145: 40-49. PMID 16225937.

[2] Bader, S., Kortholt, A., Snippe, H. and Van Haastert, P.J. (2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281: 20018-20026. PMID 16644729.

[3] Rascón, A., Soderling, S.H., Schaefer, J.B. and Beavo, J.A. (2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA 99: 4714-4719. PMID 11930017.

[4] Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25-25. PMID 16522215.

[5] Lugnier, C., Keravis, T., Le Bec, A., Pauvert, O., Proteau, S. and Rousseau, E. (1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta 1472: 431-446. PMID 10564757.

[6] Imamura, R., Yamanaka, K., Ogura, T., Hiraga, S., Fujita, N., Ishihama, A. and Niki, H. (1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271: 25423-25429. PMID 8810311.

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[2]

[3]

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3',5'-Ciklični-AMP fosfodiestaraza

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]

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