Proteinska fosfataza 2 (PP2), takođe poznata kao PP2A, je enzim koji je kod ljudi kodiran PPP2CAgenom.[1] PP2A heterotrimerna proteinska fosfataza, je široko zastupljena i konservirana serin/treoninska fosfataza sa širokom supstratnom specifičnošću i različitim ćelijskim funkcijama. Među PP2A metama su proteini onkogene signalne kaskade, poput Raf, MEK, i AKT.
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Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y (December 2006). „Structure of the protein phosphatase 2A holoenzyme”. Cell127 (6): 1239–51. DOI:10.1016/j.cell.2006.11.033. PMID17174897.
Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y (October 2006). „Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins”. Cell127 (2): 341–53. DOI:10.1016/j.cell.2006.09.025. PMID17055435.
Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK (August 2003). „Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites”. Curr. Biol.13 (16): 1356–64. DOI:10.1016/S0960-9822(03)00535-9. PMID12932319.