Fosfolipaza A1
Izgled
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Mesta razlaganja fosfolipazom. Enzim sa PLA1 i PLA2 dejstvom se naziva fosfolipaza B | |||||||||
Identifikatori | |||||||||
EC broj | 3.1.1.32 | ||||||||
CAS broj | 9043-29-2 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
Ontologija gena | AmiGO / EGO | ||||||||
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Fosfolipaza A1 član A | |
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Identifikatori | |
Simbol | PLA1A |
Entrez | 51365 |
Hugo | 17661 |
OMIM | 607460 |
RefSek | NM_015900 |
UniProt | Q53H76 |
Drugi podaci | |
EC broj | 3.1.1.32 |
Lokus | Hrom. 3 q13.13-13.2 |
Fosfolipaza A1 (EC 3.1.1.32) je fosfolipazni enzim koji uklanja 1-acil.[1] Njegovo sistematskim ime je fosfatidilholin 1-acilhidrolaza.[2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfatidilholin + H2O 2-acilglicerofosfoholin + karboksilat
Ovaj enzim ima znatno širu specifičnost od enzima EC 3.1.1.4, fosfolipaze A2. Za njegov rad je neophodan jon Ca2+.
Fosfolipaza A1 je komponenta zmijskog otrova, ali se takođe učestvuje i u normalnom metabolizmu pri formiranju masnih kiselina iz fosfolipida. U melanocitnim ćelijama gen fosfolipaze A1 može da bude regulisan MITF-om[6].
- ↑ MeSH Phospholipase+A1
- ↑ Gatt, S. (1968). „Purification and properties of phospholipase A-1 from rat and calf brain”. Biochim. Biophys. Acta 159: 304-316. PMID 5657461.
- ↑ Scandella, C.J. and Kornberg, A. (1971). „A membrane-bound phospholipase A1 purified from Escherichia coli”. Biochemistry 10: 4447-4456. PMID 4946924.
- ↑ van den Bosch, H. (1980). „Intracellular phospholipases A”. Biochim. Biophys. Acta 604: 191-246. PMID 6252969.
- ↑ van den Bosch, H., Aarsman, A.J. and van Deenen, L.L.M. (1974). „Isolation and properties of a phospholipase A1 activity from beef pancreas”. Biochim. Biophys. Acta 348: 197-209. PMID 4858811.
- ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). „Novel MITF targets identified using a two-step DNA microarray strategy”. Pigment Cell Melanoma Res. 21 (6): 665–76. DOI:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.