Eksoribonukleaza II
(Preusmjereno sa stranice Eksoribonukleaza)
| Eksoribonukleaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.13.1 | ||||||||
| CAS broj | 37288-24-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Eksoribonukleaza II (EC 3.1.13.1, ribonukleaza II, ribonukleaza Q, BN ribonukleaza, Escherichia coli ekso-RNaza II, RNaza II, eksoribonukleaza, 5'-eksoribonukleaza) je enzim sa sistematskim imenom '.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eksonukleolitičko razlaganje u 3'- ka 5'- smeru čime se formiraju nukleozid 5'-fosfati
Ova enzim preferentno deluje na jednolačanu DNK.
Reference[uredi | uredi kod]
- ↑ Nossal, N.G. and Singer, M. (1968). „The processive degradation of individual polyribonucleotide chains. I. Escherichia coli ribonuclease II”. J. Biol. Chem. 243: 913-922. PMID 4867942.
- ↑ Schmidt, F.J. and McClain, W.H. (1978). „An Escherichia coli ribonuclease which removes an extra nucleotide from a biosynthetic intermediate of bacteriophage T4 proline transfer RNA”. Nucleic Acids Res. 5: 4129-4139. PMID 364422.
- ↑ Shimura, Y., Sakano, H. and Nagawa, F. (1978). „Specific ribonucleases involved in processing of tRNA precursors of Escherichia coli. Partial purification and some properties”. Eur. J. Biochem. 86: 267-281. PMID 350582.
- ↑ Sporn, M.B., Lazarus, H.M. Smith, J.M. and Henderson, W.R. (1969). „Studies on nuclear exoribonucleases. 3. Isolation and properties of the enzyme from normal and malignant tissues of the mouse”. Biochemistry 8: 1698-1706. PMID 5805304.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.