D -Manitol
(IUPAC ) ime
(2R ,3R ,4R ,5R )-Heksan-1,2,3,4,5,6-heksol
Klinički podaci
AHFS/Drugs.com
Monografija
Identifikatori
CAS broj
69-65-8
ATC kod
A06 AD16 B05 BC01 B05 CX04 R05 CB16
PubChem [1] [2] 6251
DrugBank
DB00742
ChemSpider [3] 6015
UNII
3OWL53L36A Y
KEGG [4] D00062 Y
ChEBI
CHEBI:16899 Y
ChEMBL [5] CHEMBL689 Y
Hemijski podaci
Formula
C 6 H 14 O 6
Mol. masa
182,172
SMILES
eMolekuli PubHem
InChI InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1 Y Y
Farmakokinetički podaci
Bioraspoloživost
~7%
Metabolizam
Hepatički , zanemarljiv.
Poluvreme eliminacije
100 minuta
Izlučivanje
Renalno : 90%
Farmakoinformacioni podaci
Trudnoća
?
Pravni status
Način primene
IV Oralno
Manitol je beli, kristalni[6] šećerni alkohol sa hemijskom formulom (C6 H8 (OH)6 ). On se koristi kao osmotički diuretički agens i slab renalni vazodilatator . On je originalno bio izolovan iz sekreta crnog jasena .[7] osmotskog stresa .
Manitol je šećerni alkohol . On se formira redukcijom šećera. Njegova molekulska masa je 182,17 g/mol[8] gustina 1,52 g/mL.[9] ksilitol i sorbitol . Manitol i sorbitol su izomeri. Oni se razlikuju samo po orijentaciji hidroksilne grupe na ugljeniku 2.[10] kiseli . D-Mannitol (CAS# 69-65-8) ima rastvorljivost od 22 g manitola/ 100 mL vode (25 °C), i relativnu slatkošu od 50 (saharoza = 100).[8] tor ), i ključa na 295 °C pri 3.5 tor.[9]
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery." . Drug Discov Today 15 (23-24): 1052-7. DOI :10.1016/j.drudis.2010.10.003 . PMID 20970519 . http://www.sciencedirect.com/science/article/pii/S1359644610007737 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4 : 217-241. DOI :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining" . J Cheminform 2 (1): 3. DOI :10.1186/1758-2946-2-3 . PMID 20331846 . http://www.jcheminf.com/content/2/1/3 . edit ↑ Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG" . Yeast 17 (1): 48–55. DOI :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI :10.1093/nar/gkr777 . PMID 21948594 . edit ↑ Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225.
↑ Cooley's Cyclopaedia of Practical Receipts, 6th ed. (1880)
↑ 8,0 8,1 Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225
↑ 9,0 9,1 D-Mannitol (accessed November 11, 2010).↑ Kearsley, M. W.; Deis, R. C. Sorbitol and Mannitol. In Sweeteners and Sugar Alternatives in Food Technology; Ames: Oxford, 2006; pp 249-249-261.
Šablon:Diuretici
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