Manitol

D-Manitol
(IUPAC) ime
	(2R,3R,4R,5R)-Heksan-1,2,3,4,5,6-heksol
Klinički podaci
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	69-65-8
ATC kod	A06AD16 B05BC01 B05CX04 R05CB16
PubChem	6251
DrugBank	DB00742
ChemSpider	6015
UNII	3OWL53L36A
KEGG	D00062
ChEBI	CHEBI:16899
ChEMBL	CHEMBL689
Hemijski podaci
Formula	C6H14O6
Mol. masa	182,172
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1 ; Key: FBPFZTCFMRRESA-KVTDHHQDSA-N
Farmakokinetički podaci
Bioraspoloživost	~7%
Metabolizam	Hepatički, zanemarljiv.
Poluvreme eliminacije	100 minuta
Izlučivanje	Renalno: 90%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	IV; Oralno

Manitol je beli, kristalni^[6] šećerni alkohol sa hemijskom formulom (C₆H₈(OH)₆). On se koristi kao osmotički diuretički agens i slab renalni vazodilatator. On je originalno bio izolovan iz sekreta crnog jasena.^[7] On se u biljkama koristi za indukovanje osmotskog stresa.

Hemija[uredi - уреди | uredi kôd]

Manitol je šećerni alkohol. On se formira redukcijom šećera. Njegova molekulska masa je 182,17 g/mol^[8] a gustina 1,52 g/mL.^[9] Drugi srodni šećerni alkoholi su ksilitol i sorbitol. Manitol i sorbitol su izomeri. Oni se razlikuju samo po orijentaciji hidroksilne grupe na ugljeniku 2.^[10] Vodeni rastvori manitola su blago kiseli. D-Mannitol (CAS# 69-65-8) ima rastvorljivost od 22 g manitola/ 100 mL vode (25 °C), i relativnu slatkošu od 50 (saharoza = 100).^[8] On se topi između 165 i 169 °C (7.6 tor), i ključa na 295 °C pri 3.5 tor.^[9]

Reference[uredi - уреди | uredi kôd]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225.
↑ Cooley's Cyclopaedia of Practical Receipts, 6th ed. (1880)
↑ ^8,0 ^8,1 Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225
↑ ^9,0 ^9,1 D-Mannitol (accessed November 11, 2010).
↑ Kearsley, M. W.; Deis, R. C. Sorbitol and Mannitol. In Sweeteners and Sugar Alternatives in Food Technology; Ames: Oxford, 2006; pp 249-249-261.

Spoljašnje veze[uredi - уреди | uredi kôd]

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Lawson,_P_pp_219-225-6] Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225.

[7] Cooley's Cyclopaedia of Practical Receipts, 6th ed. (1880)

[ReferenceA-8] 8,0 ^8,1 Lawson, P. In In Mannitol; Blackwell Publishing Ltd: 2007; pp 219-225

[toxnet.nlm.nih.gov-9] 9,0 ^9,1 D-Mannitol (accessed November 11, 2010).

[Kearsley,_M._W._pp_249-249-10] Kearsley, M. W.; Deis, R. C. Sorbitol and Mannitol. In Sweeteners and Sugar Alternatives in Food Technology; Ames: Oxford, 2006; pp 249-249-261.

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Manitol

Hemija[uredi - уреди | uredi kôd]

Reference[uredi - уреди | uredi kôd]

Spoljašnje veze[uredi - уреди | uredi kôd]

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