Antireumatski lek
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Antireumatski lekovi (DMARDs) su kategorija lekova koji se koriste za tretman reumatoidnog artritisa. Njima se usporava progresija bolesti.[1][2].[3]
Članovi[uredi - уреди | uredi kôd]
| Lek | Mehanizam |
|---|---|
| abatacept | T-ćelijski kostimulatorni inhibitor signala |
| adalimumab | TNF inhibitor |
| azatioprin | Inhibitor purinske sinteze |
| hlorohin i hidroksihlorohin (antimalarijali) | Supresija IL-1 & TNF-alfa, indukuje apoptozu inflamatornih ćelija i umanjuje hemotaksu |
| ciclosporin (Ciklosporin A) | kalcineurinski inhibitor |
| D-penicilamin | Redukuje broj T-limfocita etc. |
| etanercept | TNF receptor |
| golimumab | TNF inhibitor |
| Soli zlata (natrijum aurotiomalat, auranofin) | unknown |
| infliksimab | TNF inhibitor |
| leflunomid | Inhibitor sinteze pirimidina |
| metotreksat (MTX) | Inhibitor sinteze purina |
| minociklin | 5-LO inhibitor |
| rituksimab | himerno monoklonalno antitelo protiv CD20 na površini B-ćelija |
| sulfasalazin (SSZ) | Supresuje IL-1 & TNF-alfa, indukuje apoptozu inflamatornih ćelije i povišava nivo hemotaktičkih faktora |
Mada ovi agensi deluju putem različitih mehanizama, mnogi od njih imaju sličan impakt na tok oboljenja.[4] Neki od ovih lekova se mogu koristiti u kombinaciji.[5]
Reference[uredi - уреди | uredi kôd]
- ↑ „disease-modifying antirheumatic drug at Dorland's Medical Dictionary”. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/nine/14176078.htm.
- ↑ „Disease modifying antirheumatic drugs (DMARDs)”. http://www.uptodate.com/patients/content/topic.do?topicKey=arth_rhe/5016.
- ↑ „Antirheumatic at Dorland's Medical Dictionary”. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000006317.htm.
- ↑ Nandi P, Kingsley GH, Scott DL (May 2008). „Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid arthritis and seronegative arthritis”. Current opinion in rheumatology 20 (3): 251–6. DOI:10.1097/BOR.0b013e3282fb7caa. PMID 18388514. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00002281-200805000-00005.
- ↑ Capell HA, Madhok R, Porter DR, et al. (February 2007). „Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double‐blind placebo‐controlled MASCOT study”. Annals of the rheumatic diseases 66 (2): 235–41. DOI:10.1136/ard.2006.057133. PMC 1798490. PMID 16926184. http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=16926184.
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