WAY-213,613

Izvor: Wikipedia
WAY-213,613
(IUPAC) ime
(2S)-2-amino-4-[4-(2-bromo-4,5-difluorofenoksi)anilino]-4-oksobutanoinska kiselina
Klinički podaci
Identifikatori
CAS broj 868359-05-1
ATC kod nije dodeljen
PubChem[1][2] 11531745
Hemijski podaci
Formula C16H13BrF2N2O4 
Mol. masa 415,186 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

WAY-213,613 je lek koji deluje kao inhibitor preuzimanja za podtip glutamatnog transportera EAAT2. On je selektivan u odnosu na druge podtipove glutamatnih transportera, i visoko je selektivan u odnosu na metabotropne i jonotropne glutamatne receptore.[3] It is used in scientific research into the function of the glutamate transporters.[4]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A et al. (2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807. 
  4. Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521. 

Spoljašnje veze[uredi - уреди]