DCPG

Izvor: Wikipedia
DCPG
(IUPAC) ime
4-[(1S)-1-amino-2-hidroksi-2-oksoetil]ftalna kiselina
Klinički podaci
Identifikatori
CAS broj 201730-11-2
ATC kod nije dodeljen
PubChem[1][2] 16062593
Hemijski podaci
Formula C10H9NO6 
Mol. masa 239,181 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

DCPG ((S)-3,4-DCPG) je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan agonist za metabotropni glutamatni receptor mGluR8. On ima antikonvulzivno dejstvo u životinjskim studijama.[3][4] On je takođe istraživan kao mogući tretman za hiperalgeziju.[5]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 2003 Aug 22;476(1-2):3-16. DOI:10.1016/S0014-2999(03)02149-6 PMID 12969743
  4. Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. Neuropharmacology. 2008 Mar;54(4):665-75. PMID 18191956
  5. Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. PMID 17113112

Spoljašnje veze[uredi - уреди]