L-AP4

Izvor: Wikipedia
L-AP4
(IUPAC) ime
(2S)-2-amino-4-fosfonobutanoinska kiselina
Klinički podaci
Identifikatori
CAS broj 23052-81-5
ATC kod nije dodeljen
PubChem[1][2] 179394
Hemijski podaci
Formula C4H10NO5P 
Mol. masa 183,099 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

L-AP4 je lek koji se koristi u naučnim istraživanjima. On deluje kao agonist koji je selektivan za grupu III metabotropnih glutamatnih receptora (mGluR4/6/7/8). On je bio privi ligand za koji je utvrđeno da deluje kao selektivni agonist za ovu grupu mGlu receptora.[3] On se koristi u izučavanju ove receptorske familije i njihovih funkcija.[4][5][6][7]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Thomsen C (1997). "The L-AP4 receptor". General pharmacology 29 (2): 151–8. PMID 9251893. 
  4. Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (2007). "Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease". Journal of Neuroscience 27 (25): 6701–11. doi:10.1523/JNEUROSCI.0299-07.2007. PMID 17581957. 
  5. MacInnes N, Duty S (2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo". European journal of pharmacology 580 (1–2): 95–9. doi:10.1016/j.ejphar.2007.10.030. PMID 18035348. 
  6. Zhang HM, Chen SR, Pan HL (2009). "Effects of Activation of Group III Metabotropic Glutamate Receptors on Spinal Synaptic Transmission in a Rat Model of Neuropathic Pain". Neuroscience 158 (2): 875–84. doi:10.1016/j.neuroscience.2008.10.042. PMC 2649787. PMID 19017536. 
  7. MacIejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, Lehner M, Bidziński A, Hamed A (2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration". Brain research 1282: 20–7. doi:10.1016/j.brainres.2009.05.049. PMID 19481536. 

Spoljašnje veze[uredi - уреди]