Dipiridamol

Iz Wikipedije, slobodne enciklopedije
Dipiridamol
(IUPAC) ime
2,2',2'',2'''-(4,8-di(piperidin-1-il)pirimido[5,4-d]pirimidin-2,6-diil)bis(azanetriil)tetraetanol
Klinički podaci
Robne marke Persantin
AHFS/Drugs.com Monografija
MedlinePlus a682830
Identifikatori
CAS broj 58-32-2
ATC kod B01AC07
PubChem[1][2] 3108
DrugBank DB00975
ChemSpider[3] 2997
UNII 64ALC7F90C YesY
KEGG[4] D00302 YesY
ChEBI CHEBI:4653 YesY
ChEMBL[5] CHEMBL932 YesY
Hemijski podaci
Formula C24H40N8O4 
Mol. masa 504,626 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Vezivanje za proteine plazme 99%
Metabolizam Hepatic
Poluvreme eliminacije Alfa (40 min), Beta (10 sati)
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status POM (UK) -only (SAD)
Način primene PO, IV

Dipiridamol (Persantin, Antistenokardin) je lek koji inhibira formiranje tromba[6] pri hroničnoj primeni i uzrokuje vazodilataciju kad se koristi u visokim dozama tokom kratkog vremenskog intervala.

Mehanizam i dejstvo[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. "Dipyridamole at Dorland's Medical Dictionary". http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/three/000030395.htm. 

Vidi još[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]


Star of life.svg Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).