Teobromin

Teobromin
(IUPAC) ime
	3,7-dimetil-1H-purin-2,6-dion
Klinički podaci
Identifikatori
CAS broj	83-67-0
ATC kod	C03BD01 R03DA07
PubChem	5429
DrugBank	DB01412
ChemSpider	5236
UNII	OBD445WZ5P
KEGG	C07480
ChEBI	CHEBI:28946
ChEMBL	CHEMBL1114
Hemijski podaci
Formula	C7H8N4O2
Mol. masa	180,164 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)9-7(13)11(5)2/h3H,1-2H3,(H,9,12,13) ; Key: YAPQBXQYLJRXSA-UHFFFAOYSA-N
Sinonimi	ksanteoza; diurobromin; 3,7-dimetilksantin
Farmakokinetički podaci
Metabolizam	Hepatički demetilacija i oksidacija
Poluvreme eliminacije	7,1 +/- 0,7 sata
Izlučivanje	Renalno (10% nepromenjen, ostalo kao metaboliti)
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	nije kontrolisana supstanca
Način primene	Oralno

Teobromin je gorki alkaloid iz kakao biljke. On je prisutan u čokoladi, kao i u brojnim drugim prehrambenim proizvodima, uključujući lišće biljki čaja, i u kola orasima. On pripada metilksantinskoj klasi hemijskih jedinjenja,^[8] koja isto tako obuhvata teofilin i kofein.^[6] Kofein se razlikuje po tome što je jedna NH grupa teobromina metilisana. Uprkos njegovog imena, ovo jedinjenje ne sadrži brom — teobromin je reč izvedena iz Theobroma, imena roda kakao drveta.^[9] Sufiks -in se koristi za imena alkaloida i drugih baznih jedinjenja koja sadrže azot.^[10]

Teobromin je malo rastvoran u vodi (330 mg/L), kristalni, gorki prah. Njegova boja je bilo bela ili je bezbojan.^[11] On ima slično, ali manje jako dejstvo od kofeina u ljudskom nervnom sistemu. Teobromin je izomer teofilina, kao i paraksantina. Teobromin se klasifikuje kao dimetilni ksantin.^[12]

Reference[uredi - уреди | uredi izvor]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit
↑ Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^6,0 ^6,1 William Marias Malisoff (1943). Dictionary of Bio-Chemistry and Related Subjects. Philosophical Library. str. 311, 530, 573. ISBN B0006AQ0NU.
↑ ^7,0 ^7,1 ((fr)) "Theobromine". BIAM. 29. 3. 2000.. http://www.biam2.org/www1/Sub1331.html. Pristupljeno 1. 3. 2007..
↑ Baer, Donald M.; Elsie M. Pinkston (1997). Environment and Behavior. Westview Press. str. 200.
↑ Bennett, Alan Weinberg; Bonnie K. Bealer (2002). The World of Caffeine: The Science and Culture of the World's Most Popular Drug. Routledge, New York. ISBN 0-415-92723-4.
↑ "-ine." The American Heritage Dictionary of the English Language, Fourth Edition. Houghton Mifflin Company. 2004. ISBN 0-395-71146-0. http://dictionary.reference.com/browse/-ine.
↑ "theobromine". Dictionary.com. http://dictionary.reference.com/search?q=theobromine&db=*. Pristupljeno 22. 2. 2007..
↑ "Theobromine". On-Line Medical Dictionary. http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=theobromine&action=Search+OMD. Pristupljeno 23. 2. 2007..

Literatura[uredi - уреди | uredi izvor]

Bennett, Alan Weinberg; Bonnie K. Bealer (2002). The World of Caffeine: The Science and Culture of the World's Most Popular Drug. Routledge, New York. ISBN 0-415-92723-4.
Baer, Donald M.; Elsie M. Pinkston (1997). Environment and Behavior. Westview Press. str. 200.
William Marias Malisoff (1943). Dictionary of Bio-Chemistry and Related Subjects. Philosophical Library. str. 311, 530, 573. ISBN B0006AQ0NU.

Bender, David A.; Arnold E. Bender (1995). A Dictionary of Food and Nutrition. Oxford: Oxford University Press. ISBN 0-19-860961-2.

Spoljašnje veze[uredi - уреди | uredi izvor]

	Portal Medicina
	Portal Hemija

Šablon:Diuretici

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3. edit

[4] Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[dictbiochem1943-6] 6,0 ^6,1 William Marias Malisoff (1943). Dictionary of Bio-Chemistry and Related Subjects. Philosophical Library. str. 311, 530, 573. ISBN B0006AQ0NU.

[BIAM-7] 7,0 ^7,1 ((fr)) "Theobromine". BIAM. 29. 3. 2000.. http://www.biam2.org/www1/Sub1331.html. Pristupljeno 1. 3. 2007..

[envbeh-p200-8] Baer, Donald M.; Elsie M. Pinkston (1997). Environment and Behavior. Westview Press. str. 200.

[worldofcaffeine-9] Bennett, Alan Weinberg; Bonnie K. Bealer (2002). The World of Caffeine: The Science and Culture of the World's Most Popular Drug. Routledge, New York. ISBN 0-415-92723-4.

[dict-ine-10] "-ine." The American Heritage Dictionary of the English Language, Fourth Edition. Houghton Mifflin Company. 2004. ISBN 0-395-71146-0. http://dictionary.reference.com/browse/-ine.

[theobromine-chemprops-11] "theobromine". Dictionary.com. http://dictionary.reference.com/search?q=theobromine&db=*. Pristupljeno 22. 2. 2007..

[omd-theobromine-12] "Theobromine". On-Line Medical Dictionary. http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=theobromine&action=Search+OMD. Pristupljeno 23. 2. 2007..

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Teobromin

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

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