Aminofilin

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Aminofilin
(IUPAC) ime
1,3-dimetil-7H-purin-2,6-dion; ethan-1,2-diamin
Klinički podaci
AHFS/Drugs.com Potrošačka informacije o leku
MedlinePlus a601015
Identifikatori
CAS broj 317-34-0
ATC kod R03DA05
PubChem[1][2] 9433
DrugBank DB01223
ChemSpider[3] 9062
UNII 27Y3KJK423 YesY
KEGG[4] D00227 YesY
ChEMBL[5] CHEMBL1210 YesY
Hemijski podaci
Formula C16H24N10O4 
Mol. masa 420,427 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Vezivanje za proteine plazme 60%
Poluvreme eliminacije 7-9 sata
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status P (UK)
Način primene oralno, i.v.

Aminofilin je bronhodilatator. On se sastoji od teofilina sa etilendiaminom u odnosu 2:1. Etilendiamin poboljšava rastvorljivost. Aminofilin se obično nalazi kao dihidrat[6] Aminofilin je neselektivan antagonist adenozinskog receptora i inhibitor fosfodiesteraze.[7][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. "Aminophylline Professional Monograph". http://www.drugs.com/pro/aminophylline-injection.html. 
  7. 7,0 7,1 Mader, TJ; Smithline HA, Durkin L, Scriver G (March 2003). "A randomized control trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest". Academic Emergency Medical Journal 10 (3): 192–197. Pristupljeno 2012-02-10. 
  8. Mader, TJ; Gibson, P (January 1997). cws_home/505959/description#description "Adenosine receptor antagonism in refractory asystolic cardiac arrest: results of a human pilot study". Elsevier Resuscitation 35: 3–7. Pristupljeno 2012-02-10. 


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