Tromboksan-A sintaza

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Tromboksan A sintaza 1 (trombocitna)
Identifikatori
SimboliTBXAS1; BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Vanjski IDOMIM274180 MGI98497 HomoloGene55549 GeneCards: TBXAS1 Gene
EC broj5.3.99.5
Pregled RNK izražavanja
PBB GE TBXAS1 208130 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez691621391
EnsemblENSG00000059377ENSMUSG00000029925
UniProtP24557P36423
RefSeq (mRNA)NM_001061.4NM_011539.3
RefSeq (protein)NP_001052.2NP_035669.3
Lokacija (UCSC)Chr 7:
139.48 - 139.72 Mb
Chr 6:
38.88 - 39.08 Mb
PubMed pretraga[1][2]

Tromboksan-A sintaza 1 (EC 5.3.99.5, trombocit, citohrom P450, familija 5, potfamilija A), takođe poznata kao TBXAS1, je enzim koji je kod ljudi kodiran TBXAS1 genom.[1][2][3]

Reference[uredi - уреди | uredi izvor]

  1. "Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6916. 
  2. Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (August 1991). "Molecular cloning of human platelet thromboxane A synthase". Biochem. Biophys. Res. Commun. 178 (3): 1479–1484. PMID 1714723. doi:10.1016/0006-291X(91)91060-P. 
  3. Baek SJ, Lee KD, Shen RF (September 1996). "Genomic structure and polymorphism of the human thromboxane synthase-encoding gene". Gene 173 (2): 251–256. PMID 8964509. doi:10.1016/0378-1119(95)00881-0. 

Literatura[uredi - уреди | uredi izvor]

  • Shen RF, Tai HH (1998). "Thromboxanes: synthase and receptors". J. Biomed. Sci. 5 (3): 153–172. PMID 9678486. doi:10.1007/BF02253465. 
  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–1165. PMID 9890157. doi:10.1080/004982598238868. 
  • Wang LH, Kulmacz RJ (2003). "Thromboxane synthase: structure and function of protein and gene". Prostaglandins Other Lipid Mediat. 68-69: 409–422. PMID 12432933. doi:10.1016/S0090-6980(02)00045-X. 
  • Itoh S; Yanagimoto T; Tagawa S et al. (1992). "Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region". Biochim. Biophys. Acta 1130 (2): 133–8. PMID 1562592. 
  • Yokoyama C; Miyata A; Ihara H et al. (1991). "Molecular cloning of human platelet thromboxane A synthase". Biochem. Biophys. Res. Commun. 178 (3): 1479–1484. PMID 1714723. doi:10.1016/0006-291X(91)91060-P. 
  • Ohashi K; Ruan KH; Kulmacz RJ et al. (1992). "Primary structure of human thromboxane synthase determined from the cDNA sequence". J. Biol. Chem. 267 (2): 789–93. PMID 1730669. 
  • Jones DA, Fitzpatrick FA, Malcolm KC (1991). "Thromboxane A2 synthesis in human erythroleukemia cells". Biochem. Biophys. Res. Commun. 180 (1): 8–14. PMID 1930241. doi:10.1016/S0006-291X(05)81247-1. 
  • Wang LH, Ohashi K, Wu KK (1991). "Isolation of partial complementary DNA encoding human thromboxane synthase". Biochem. Biophys. Res. Commun. 177 (1): 286–291. PMID 2043115. doi:10.1016/0006-291X(91)91980-Q. 
  • Nüsing R, Schneider-Voss S, Ullrich V (1990). "Immunoaffinity purification of human thromboxane synthase". Arch. Biochem. Biophys. 280 (2): 325–330. PMID 2195994. doi:10.1016/0003-9861(90)90337-X. 
  • Mestel F; Oetliker O; Beck E et al. (1980). "Severe bleeding associated with defective thromboxane synthetase". Lancet 1 (8160): 157. PMID 6101498. doi:10.1016/S0140-6736(80)90642-X. 
  • Miyata A; Yokoyama C; Ihara H et al. (1994). "Characterization of the human gene (TBXAS1) encoding thromboxane synthase". Eur. J. Biochem. 224 (2): 273–279. PMID 7925341. doi:10.1111/j.1432-1033.1994.00273.x. 
  • Wang LH, Tazawa R, Lang AQ, Wu KK (1995). "Alternate splicing of human thromboxane synthase mRNA". Arch. Biochem. Biophys. 315 (2): 273–278. PMID 7986068. doi:10.1006/abbi.1994.1500. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Lee KD, Baek SJ, Shen RF (1994). "Cloning and characterization of the human thromboxane synthase gene promoter". Biochem. Biophys. Res. Commun. 201 (1): 379–387. PMID 8198598. doi:10.1006/bbrc.1994.1712. 
  • Chase MB; Baek SJ; Purtell DC et al. (1993). "Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization". Genomics 16 (3): 771–773. PMID 8325653. doi:10.1006/geno.1993.1264. 
  • Ruan KH, Wang LH, Wu KK, Kulmacz RJ (1993). "Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum". J. Biol. Chem. 268 (26): 19483–90. PMID 8366093. 
  • Tazawa R; Green ED; Ohashi K et al. (1996). "Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter". Arch. Biochem. Biophys. 334 (2): 349–356. PMID 8900410. doi:10.1006/abbi.1996.0464. 
  • Baek SJ, Lee KD, Shen RF (1996). "Genomic structure and polymorphism of the human thromboxane synthase-encoding gene". Gene 173 (2): 251–256. PMID 8964509. doi:10.1016/0378-1119(95)00881-0. 
  • Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 

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