DDR2 (gen)

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Diskoidin domen receptor familija, izoforma 2
Identifikatori
Simboli DDR2; MIG20a; NTRKR3; TKT; TYRO10
Vanjski ID OMIM191311 MGI1345277 HomoloGene68505 GeneCards: DDR2 Gene
Pregled RNK izražavanja
PBB GE DDR2 205168 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4921 18214
Ensembl ENSG00000162733 ENSMUSG00000026674
UniProt Q16832 Q62371
RefSeq (mRNA) NM_001014796 NM_022563
RefSeq (protein) NP_001014796 NP_072075
Lokacija (UCSC) Chr 1:
160.87 - 161.02 Mb
Chr 1:
171.81 - 171.95 Mb
PubMed pretraga [1] [2]

DDR2, ili CD167b (klaster diferencijacije 167b), je ljudski gen [1], koji je član broj 2 familije diskoidin domen receptora.

Receptor tirozin kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su vezani za regulaciju ćelijskog rasta, diferencijacije i metabolizma. U više slučajeva biohemijski mehanizam kojim RTK sprovodi signal kroz membranu je pokazan da se sastoji od ligand indukovane oligomerizacije receptora, i naknadne intracelularna fosforilacije. Ova autofosforilacija dovodi do naknadne fosforilacije citosolnih proteina, kao i do asocijacije sa drugim molekulima koji su vezani za pleiotropske efekte transdukcije signala. RTK proteini imaju trojnu strukturu koja se sastoji od ekstracelularnog, transmembranskog, i citoplazmatičnog regiona. Ovaj gen kodira pripadnika nove RTK podklase sa različitim ekstracelularnim regionom koji okružuje domen sličan faktoru VIII. Alternativno spajanje (eng. splicing ) ovog gena na 5' UTR dovodi do nekoliko transkript varijanti.[1]

Interakcije[uredi - уреди]

Demonstrirano je da DDR2 ima protein-protein interakciju sa SHC1.[2]

Literatura[uredi - уреди]

Dadatna literatura[uredi - уреди]

  • Lapsys NM, Layfield R, Baker E, et al. (1993). "Chromosomal location of the human transketolase gene.". Cytogenet. Cell Genet. 61 (4): 274–5. PMID 1486804. 
  • Abedinia M, Layfield R, Jones SM, et al. (1992). "Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase.". Biochem. Biophys. Res. Commun. 183 (3): 1159–66. PMID 1567394. 
  • Edelhoff S, Sweetser DA, Disteche CM (1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C.". Genomics 25 (1): 309–11. PMID 7774938. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Karn T, Holtrich U, Bräuninger A, et al. (1993). "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain.". Oncogene 8 (12): 3433–40. PMID 8247548. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Vogel W, Gish GD, Alves F, Pawson T (1998). "The discoidin domain receptor tyrosine kinases are activated by collagen.". Mol. Cell 1 (1): 13–23. PMID 9659899. 
  • Mohan RR, Mohan RR, Wilson SE (2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea.". Exp. Eye Res. 72 (1): 87–92. doi:10.1006/exer.2000.0932. PMID 11133186. 
  • Ikeda K, Wang LH, Torres R, et al. (2002). "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.". J. Biol. Chem. 277 (21): 19206–12. doi:10.1074/jbc.M201078200. PMID 11884411. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Faraci E, Eck M, Gerstmayer B, et al. (2004). "An extracellular matrix-specific microarray allowed the identification of target genes downstream of discoidin domain receptors.". Matrix Biol. 22 (4): 373–81. PMID 12935821. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Ferri N, Carragher NO, Raines EW (2004). "Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis.". Am. J. Pathol. 164 (5): 1575–85. PMID 15111304. 
  • Leitinger B, Steplewski A, Fertala A (2005). "The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2.". J. Mol. Biol. 344 (4): 993–1003. doi:10.1016/j.jmb.2004.09.089. PMID 15544808. 
  • Wall SJ, Werner E, Werb Z, DeClerck YA (2006). "Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.". J. Biol. Chem. 280 (48): 40187–94. doi:10.1074/jbc.M508226200. PMID 16186104. 
  • Yang K, Kim JH, Kim HJ, et al. (2006). "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.". J. Biol. Chem. 280 (47): 39058–66. doi:10.1074/jbc.M506921200. PMID 16186108. 
  • Leitinger B, Kwan AP (2007). "The discoidin domain receptor DDR2 is a receptor for type X collagen.". Matrix Biol. 25 (6): 355–64. doi:10.1016/j.matbio.2006.05.006. PMID 16806867. 
  • Zhang W, Ding T, Zhang J, et al. (2007). "Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells.". Mol. Cell. Biochem. 290 (1-2): 43–53. doi:10.1007/s11010-006-9136-4. PMID 16967187. 
  • Ford CE, Lau SK, Zhu CQ, et al. (2007). "Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.". Br. J. Cancer 96 (5): 808–14. doi:10.1038/sj.bjc.6603614. PMID 17299390.