Serin/treoninska proteinska kinaza LMTK1

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Tirozinska kinaza asocirana sa apoptozom
Identifikatori
SimboliAATK; AATYK; AATYK1; LMR1; LMTK1; PPP1R77; p35BP
Vanjski IDOMIM605276 MGI1197518 HomoloGene74861 GeneCards: AATK Gene
EC broj2.7.11.1
Ortolozi
VrstaČovekMiš
Entrez962511302
EnsemblENSG00000181409ENSMUSG00000025375
UniProtQ6ZMQ8Q80YE4
Ref. Sekv. (iRNK)NM_001080395NM_001198785
Ref. Sekv. (protein)NP_001073864NP_001185714
Lokacija (UCSC)Chr 17:
79.09 - 79.14 Mb
Chr 11:
120.01 - 120.05 Mb
PubMed pretraga[1][2]

Serin/treoninska proteinska kinaza LMTK1 (takođe poznata kao tirozinska kinaza asocirana sa apoptozom) je enzim koji je kod ljudi kodiran (AATK) genom.[1][2][3]

Structura i izražavanje[uredi | uredi kod]

Ovaj gen je identifikovan 1998. On je lociran na hromozomu 17 (17q25.3) i izražava se u pankreasu, bubrezima, mozgu i plućima. Protein se sastoji od 1.207 aminokiselina.[1][2]

Funkcija[uredi | uredi kod]

Ovaj protein se sastoji od tirozinskog kinaznog domena na N-terminusnom kraju i prolinom bogatog domena na C-terminusnom kraju. Studije mišjeg homoga indiciraju da je on verovatno neophodan za indukciju zaustavljanja rasta i/ili apoptozu mijeloidnih prekursornih ćelija. On takođe učestvuje u indukciji diferencijacije u neuronskim ćelijama.[4][3] Nedavno je objavljeno da ima supresivnu ulogu u razvoju melanoma.[5]

Smatra se da AATK indirektno inhibira SPAK/WNK4 aktivaciju Na-K-Cl kotransportera.[6]

Reference[uredi | uredi kod]

  1. 1,0 1,1 Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). „Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Res 5 (3): 169–76. DOI:10.1093/dnares/5.3.169. PMID 9734811. 
  2. 2,0 2,1 Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). „Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization”. J Hum Genet 44 (2): 141–2. DOI:10.1007/s100380050130. PMID 10083745. 
  3. 3,0 3,1 „Entrez Gene: AATK apoptosis-associated tyrosine kinase”. 
  4. DOI:10.1371/journal.pone.0031022
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  5. Ma S (Apr 2014). „Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma.”. Lab Invest. 94 (4): 430-438. DOI:10.1038/labinvest.2014.13. PMID 24589855. 
  6. DOI:10.1152/ajpcell.00580.2006
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Literatura[uredi | uredi kod]

Vanjske veze[uredi | uredi kod]

  • AATK human gene location in the UCSC Genome Browser.
  • AATK human gene details in the UCSC Genome Browser.