AXL receptorska tirozinska kinaza
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| AXL receptorska tirozinska kinaza | |||||||||||
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 PDB prikaz baziran na 2c5d. | |||||||||||
| Dostupne strukture | |||||||||||
| 2C5D | |||||||||||
| Identifikatori | |||||||||||
| Simboli | AXL; JTK11; UFO | ||||||||||
| Vanjski ID | OMIM: 109135 MGI: 1347244 HomoloGene: 7583 GeneCards: AXL Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 558 | 26362 | |||||||||
| Ensembl | ENSG00000167601 | ENSMUSG00000002602 | |||||||||
| UniProt | P30530 | Q00993 | |||||||||
| Ref. Sekv. (iRNK) | NM_001278599 | NM_001190974 | |||||||||
| Ref. Sekv. (protein) | NP_001265528 | NP_001177903 | |||||||||
| Lokacija (UCSC) | Chr 19: 41.73 - 41.77 Mb | Chr 7: 25.76 - 25.79 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Tirozinski proteinski kinazni receptor UFO je enzim koji je kod ljudi kodiran AXL genom.[1][2]
Funkcija[uredi | uredi kod]
Protein kodiran ovim genom je član familije receptorskih tirozinskih kinaza. Mada je sličan drugim receptorskim tirozinskim kinazama, Axl protein ima jedinstvenu strukturu ekstracelularnog regiona koja postavlja jedno uz drugo IgL i FNIII ponavljanja. Ovaj receptor prenosi signale iz ekstracelularnog matriksa u citoplazmu u responsu na vezivanje faktora rasta. On učestvuje u stimulaciji ćelijske proliferacije. Ovaj receptor takođe može da posreduje ćelijsku agregaciju putem homofilnog vezivanja. Axl je onkogen asociran sa hroničnom mijelogenom leukemijom, kao i rakom debelog creva i melanomom. Njegov gen je lociran u blizini bcl3 onkogena, koje je u 19q13.1-q13.2. Axl gen je evoluciono konzerviran među kičmenjačkim vrstama. Poznate su dve različite alternativno splajsovane transkriptne varijante.[2]
Interakcije[uredi | uredi kod]
AXL receptorska tirozinska kinaza formira interakcije sa TENC1.[3] Axl je regulator indukovanja esencijalni epitelijalno mesenhimalne tranzicije kod matastaze raka dojke.[4]
Reference[uredi | uredi kod]
- ↑ O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET (Oct 1991). „axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase”. Mol Cell Biol 11 (10): 5016–31. PMC 361494. PMID 1656220.
- ↑ 2,0 2,1 „Entrez Gene: AXL AXL receptor tyrosine kinase”.
- ↑ Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2002). „Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin”. Biochem. Biophys. Res. Commun. 299 (5): 793–800. DOI:10.1016/S0006-291X(02)02718-3. PMID 12470648.
- ↑ Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA, Erber R, Ullrich A (2006). „Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival”. Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5799–804. DOI:10.1073/pnas.0510923103. PMC 1458653. PMID 16585512.
Literatura[uredi | uredi kod]
- Neubauer A, Burchert A, Maiwald C, et al. (1997). „Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias.”. Leuk. Lymphoma 25 (1–2): 91–6. DOI:10.3109/10428199709042499. PMID 9130617.
- Bergsagel PL, Victor-Kobrin C, Timblin CR, et al. (1992). „A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells”. J. Immunol. 148 (2): 590–6. PMID 1729376.
- Janssen JW, Schulz AS, Steenvoorden AC, et al. (1991). „A novel putative tyrosine kinase receptor with oncogenic potential”. Oncogene 6 (11): 2113–20. PMID 1834974.
- Partanen J, Mäkelä TP, Alitalo R, et al. (1991). „Putative tyrosine kinases expressed in K-562 human leukemia cells”. Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913–7. DOI:10.1073/pnas.87.22.8913. PMC 55070. PMID 2247464.
- Neubauer A, Fiebeler A, Graham DK, et al. (1994). „Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis”. Blood 84 (6): 1931–41. PMID 7521695.
- O'Bryan JP, Fridell YW, Koski R, et al. (1995). „The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage”. J. Biol. Chem. 270 (2): 551–7. DOI:10.1074/jbc.270.2.551. PMID 7822279.
- Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes”. Oncogene 8 (12): 3403–10. PMID 8247543.
- Schulz AS, Schleithoff L, Faust M, et al. (1993). „The genomic structure of the human UFO receptor”. Oncogene 8 (2): 509–13. PMID 8381225.
- O'Bryan JP, Songyang Z, Cantley L, et al. (1996). „A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain”. Proc. Natl. Acad. Sci. U.S.A. 93 (7): 2729–34. DOI:10.1073/pnas.93.7.2729. PMC 39699. PMID 8610109.
- Mark MR, Chen J, Hammonds RG, et al. (1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. PMID 8621659.
- Braunger J, Schleithoff L, Schulz AS, et al. (1997). „Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site”. Oncogene 14 (22): 2619–31. DOI:10.1038/sj.onc.1201123. PMID 9178760.
- Tanaka K, Nagayama Y, Nakano T, et al. (1998). „Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid”. Endocrinology 139 (3): 852–8. DOI:10.1210/en.139.3.852. PMID 9492013.
- Yanagita M, Arai H, Ishii K, et al. (2001). „Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis”. Am. J. Pathol. 158 (4): 1423–32. DOI:10.1016/S0002-9440(10)64093-X. PMC 1891897. PMID 11290560.
- Sun WS, Misao R, Iwagaki S, et al. (2003). „Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosis”. Mol. Hum. Reprod. 8 (6): 552–8. DOI:10.1093/molehr/8.6.552. PMID 12029073.
- D'Arcangelo D, Gaetano C, Capogrossi MC (2002). „Acidification prevents endothelial cell apoptosis by Axl activation”. Circ. Res. 91 (7): e4–12. DOI:10.1161/01.RES.0000036753.50601.E9. PMID 12364394.
- Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). „Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin”. Biochem. Biophys. Res. Commun. 299 (5): 793–800. DOI:10.1016/S0006-291X(02)02718-3. PMID 12470648.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ito M, Nakashima M, Nakayama T, et al. (2003). „Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl”. Thyroid 12 (11): 971–5. DOI:10.1089/105072502320908303. PMID 12490074.
