Src (gen)

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V-src sarkoma viralni onkogeni homolog (avijarni)

PDB prikaz baziran na 1a07.
Dostupne strukture
1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e, 1bkl, 1bkm, 1f1w, 1f2f, 1fmk, 1hcs, 1hct, 1is0, 1kc2, 1ksw, 1nlo, 1nlp, 1nzl, 1nzv, 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r, 1p13, 1prl, 1prm, 1qwe, 1qwf, 1rlp, 1rlq, 1sha, 1shb, 1shd, 1skj, 1spr, 1sps, 1srl, 1srm, 1y57, 1yi6, 1yoj, 1yol, 1yom, 2bdf, 2bdj, 2h8h, 2hwo, 2hwp, 2oiq, 2ptk, 2src
Identifikatori
Simboli SRC; ASV; SRC1; c-SRC; p60-Src
Vanjski ID OMIM190090 MGI98397 HomoloGene21120 GeneCards: SRC Gene
Pregled RNK izražavanja
PBB GE SRC 213324 at.png
PBB GE SRC 221284 s at.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6714 20779
Ensembl ENSG00000197122 ENSMUSG00000027646
UniProt P12931 Q2M4I4
RefSeq (mRNA) NM_005417 NM_001025395
RefSeq (protein) NP_005408 NP_001020566
Lokacija (UCSC) Chr 20:
35.41 - 35.47 Mb
Chr 2:
157.12 - 157.16 Mb
PubMed pretraga [1] [2]

Src je proto-onkogenska tirozinska kinaza. Src su otkrili Mihael Bišop i Harold Varmus. Za ovo otkriće im je dodeljena Nobelova nagrada za fiziologiju ili medicinu 1989. godine.[1] Ova kinaza pripada familiji nespecifičnih proteinskih tirozinskih kinaza koja se naziva Src familijom kinaza. Otkriće Src porodice proteina je imalo presudnu ulogu u modernom shvatanju rak kao bolesti u kojoj se inače zdrava ćelijska signalizacija pokvari.

Ovaj gen je sličan sa v-src genom Rous sarkoma virusa. Ovaj proto-onkogen može da igra ulogu u regulisanju embrionalnog razvoja i rasta ćelija. Proteinska kinaza koju ovaj gen kodira se može inhibirati fosforilacijom c-SRC kinazom. Mutacije ovog gena mogu da učestvuju u malignom razvoju raka debelog creva. Dve transkriptne varijante koje kodiraju isti protein su nađene za ovaj gen.[2]

Interactions[uredi - уреди]

Za Src gen je bilo pokazano da interaguje sa GRIN2A,[3][4] C-Raf,[5] CD44,[6] Jedreni translokator arilnog ugljovodoničnog receptora,[7] Aryl hydrocarbon receptor,[7] PDE6G,[8] STAT1,[9][10] EPH receptor B2,[11][12] Androgenski receptor,[13][14][15] Proteinska kinaza Mζ,[16] STAT3,[17] Grb2,[8][18] Beta-3 adrenergički receptor,[19] Kinaza beta adrenergičkog receptora,[8] Receptor epidermalnog faktora rasta,[9][20][21] PTK2,[22][23][24][25][26][27] DAB2,[28] EPS8,[29] Distroglikan,[30] Estrogenski receptor alfa,[13][31][32][33] Estrogenski receptor beta,[13][33] HNF1A,[34] KHDRBS1,[35][36][37][38][39] DDEF1,[40] MUC1,[41][42] PTK2B,[20][43][44] BCAR1,[45][22][46][47][48][24] SHB,[49] PLD2,[50] Faktor responsa seruma,[51] NCOA6,[52][53][54][55] Receptor retinoiske kiseline alfa,[32][56] Protein Viskot-Oldrić sindroma,[57][58] RICS,[59] RAS p21 proteinski activator 1,[60][61] MT-ND2[62] i GNB2L1.[63]

Reference[uredi - уреди]

  1. Nobel Prize in Physiology or Medicine for 1989 jointly to J. Michael Bishop and Harold E. Varmus for their discovery of "the cellular origin of retroviral oncogenes". Press Release.
  2. "Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6714. 
  3. Ma, Juan; Zhang Guang-Yi (Sep. 2003). "Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia". Neurosci. Lett. (Ireland) 348 (3): 185–9. doi:10.1016/S0304-3940(03)00784-5. ISSN 0304-3940. PMID 12932824. 
  4. Takagi, N; Cheung H H, Bissoon N, Teves L, Wallace M C, Gurd J W (Aug. 1999). "The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains". J. Cereb. Blood Flow Metab. (UNITED STATES) 19 (8): 880–8. doi:10.1097/00004647-199908000-00007. ISSN 0271-678X. PMID 10458595. 
  5. Cleghon, V; Morrison D K (Jul. 1994). "Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner". J. Biol. Chem. (UNITED STATES) 269 (26): 17749–55. ISSN 0021-9258. PMID 7517401. 
  6. Bourguignon, L Y; Zhu H, Shao L, Chen Y W (Mar. 2001). "CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration". J. Biol. Chem. (United States) 276 (10): 7327–36. doi:10.1074/jbc.M006498200. ISSN 0021-9258. PMID 11084024. 
  7. 7.0 7.1 Beischlag, Timothy V; Wang Song, Rose David W, Torchia Joseph, Reisz-Porszasz Suzanne, Muhammad Khurshid, Nelson Walter E, Probst Markus R, Rosenfeld Michael G, Hankinson Oliver (Jun. 2002). "Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex". Mol. Cell. Biol. (United States) 22 (12): 4319–33. doi:10.1128/MCB.22.12.4319-4333.2002. ISSN 0270-7306. PMC 133867. PMID 12024042. 
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  13. 13.0 13.1 13.2 Migliaccio, A; Castoria G, Di Domenico M, de Falco A, Bilancio A, Lombardi M, Barone M V, Ametrano D, Zannini M S, Abbondanza C, Auricchio F (Oct. 2000). "Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation". EMBO J. (ENGLAND) 19 (20): 5406–17. doi:10.1093/emboj/19.20.5406. ISSN 0261-4189. PMC 314017. PMID 11032808. 
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