RYK kinaza
(Preusmjereno sa stranice Kinaza slična receptorskoj tirozinskoj kinazi)
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| Tirozinska kinaza slična receptoru | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | RYK; D3S3195; JTK5; JTK5A; RYK1 | ||||||||||
| Vanjski ID | OMIM: 600524 MGI: 101766 HomoloGene: 68287 GeneCards: RYK Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 6259 | 20187 | |||||||||
| Ensembl | ENSG00000163785 | ENSMUSG00000032547 | |||||||||
| UniProt | P34925 | Q01887 | |||||||||
| Ref. Sekv. (iRNK) | NM_001005861 | NM_001042607 | |||||||||
| Ref. Sekv. (protein) | NP_001005861 | NP_001036072 | |||||||||
| Lokacija (UCSC) | Chr 3: 133.78 - 133.97 Mb | Chr 9: 102.83 - 102.91 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
RYK kinaza (kinaza srodna sa receptorskom tirozinskom kinazom, RYK) je gen koji kodira protein Ryk.
Ovaj protein je atipični član familije receptorskih proteinskih tirozinskih kinaza faktora rasta. On se razlikuje od drugih članova po broju konzerviranih ostataka u aktivacionom i domenu vezivanja nukleotida. Ovaj genski produkt pripada podfamiliji čiji članovi nisu regulisani fosforilacijom u aktivacionom segmentu. Pretpostavlja se da se regulacija biološke aktivnosti odvija na do sada nerazjašnjem način. Poznate su dve alternativne splajsne varijante koje kodiraju distinktne izoforme.[1]
Struktura[uredi | uredi kod]
Poput drugih receptorskih tirozinskih kinaza RYK se sastoji od tri domena, N-terminusnog ekstracelularnog ligand-vezujućeg domena, transmembranskog domena i C-terminusog intracelularnog domena. Međutim, za razliku od drugih receptorskih tirozinskih kinaza C-terminalni domen RYK ne manifestuje kinazno dejstvo.[2]
Reference[uredi | uredi kod]
- ↑ „Entrez Gene: RYK RYK receptor-like tyrosine kinase”.
- ↑ Halford, MM, and Stacker, S.A. (2001). „Revelations of the RYK receptor”. Bioessays 23 (1): 34–45. DOI:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. PMID 11135307.
Literatura[uredi | uredi kod]
- Partanen J, Mäkelä TP, Alitalo R, et al. (1991). „Putative tyrosine kinases expressed in K-562 human leukemia cells.”. Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913–8917. DOI:10.1073/pnas.87.22.8913. PMC 55070. PMID 2247464.
- Gough NM, Rakar S, Hovens CM, Wilks A (1995). „Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK.”. Mamm. Genome 6 (4): 255–6. DOI:10.1007/BF00352411. PMID 7613029.
- Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.”. Oncogene 8 (12): 3403–3410. PMID 8247543.
- Stacker SA, Hovens CM, Vitali A, et al. (1993). „Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK).”. Oncogene 8 (5): 1347–1356. PMID 8386829.
- Tamagnone L, Partanen J, Armstrong E, et al. (1993). „The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.”. Oncogene 8 (7): 2009–2014. PMID 8390040.
- Wang XC, Katso R, Butler R, et al. (1996). „H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.”. Mol. Med. 2 (2): 189–203. PMC 2230112. PMID 8726462.
- Katso RM, Russell RB, Ganesan TS (1999). „Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family.”. Mol. Cell. Biol. 19 (9): 6427–6440. PMC 84612. PMID 10454588.
- Trivier E, Ganesan TS (2002). „RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.”. J. Biol. Chem. 277 (25): 23037–43. DOI:10.1074/jbc.M202486200. PMID 11956217.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Brandenberger R, Wei H, Zhang S, et al. (2005). „Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.”. Nat. Biotechnol. 22 (6): 707–16. DOI:10.1038/nbt971. PMID 15146197.
- Lu W, Yamamoto V, Ortega B, Baltimore D (2004). „Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.”. Cell 119 (1): 97–108. DOI:10.1016/j.cell.2004.09.019. PMID 15454084.
- Watanabe A, Akita S, Tin NT, et al. (2006). „A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate.”. Cleft Palate Craniofac. J. 43 (3): 310–6. DOI:10.1597/04-145R1.1. PMID 16681403.
- Szafranski K, Schindler S, Taudien S, et al. (2007). „Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.”. Genome Biology 8 (8): R154. DOI:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.