PFKL
(Preusmjereno sa stranice PFK-B)
| edit |
| Fosfofruktokinaza, jetra | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PFKL; ATP-PFK; PFK-B; PFK-L | ||||||||||
| Vanjski ID | OMIM: 171860 MGI: 97547 HomoloGene: 55668 GeneCards: PFKL Gene | ||||||||||
| EC broj | 2.7.1.11 | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
 | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5211 | 18641 | |||||||||
| Ensembl | ENSG00000141959 | ENSMUSG00000020277 | |||||||||
| UniProt | P17858 | P12382 | |||||||||
| Ref. Sekv. (iRNK) | NM_001002021 | NM_008826 | |||||||||
| Ref. Sekv. (protein) | NP_001002021 | NP_032852 | |||||||||
| Lokacija (UCSC) | Chr 21: 45.72 - 45.75 Mb | Chr 10: 77.99 - 78.01 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
6-Fosfofruktokinaza, jetreni tip je enzim koji je kod ljudi kodiran PFKL genom.[1]
Fosfofruktokinaza (PFK) je tetramerni enzim koji katalizuje ključni korak u glikolizi, konverziju D-fruktoze 6-fosfata do D-fruktoze 1,6-bisfosfata. Zasebni genei kodiraju mišićnu podjedinicu (M) i jetrenu podjedinicu (L). PFK iz mišića je homotetramer M podjedinica, PFK iz jetre je homotetramer L-jedinica, dok se PFK iz trombocita može sastojati od bilo koje tetramerne kombinacije M i L podjedinica. Protein kodiran ovim genom je L podjedinica. Dve transkriptne varijante koje kodiraju različite izoforme su poznate.[1]
- Kahn A, Meienhofer MC, Cottreau D i dr.. (1979). „Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues”. Hum. Genet. 48 (1): 93–108. DOI:10.1007/bf00273280. PMID 156693.
- Kristensen T, Lopez R, Prydz H (1992). „An estimate of the sequencing error frequency in the DNA sequence databases”. DNA Seq. 2 (6): 343–6. DOI:10.3109/10425179209020815. PMID 1446073.
- Wang D, Fang H, Cantor CR, Smith CL (1992). „A contiguous Not I restriction map of band q22.3 of human chromosome 21”. Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3222–6. DOI:10.1073/pnas.89.8.3222. PMC 48838. PMID 1565613.
- Elson A, Levanon D, Brandeis M i dr.. (1990). „The structure of the human liver-type phosphofructokinase gene”. Genomics 7 (1): 47–56. DOI:10.1016/0888-7543(90)90517-X. PMID 2139864.
- Levanon D, Danciger E, Dafni N i dr.. (1990). „The primary structure of human liver type phosphofructokinase and its comparison with other types of PFK”. DNA 8 (10): 733–43. DOI:10.1089/dna.1989.8.733. PMID 2533063.
- Van Keuren M, Drabkin H, Hart I i dr.. (1986). „Regional assignment of human liver-type 6-phosphofructokinase to chromosome 21q22.3 by using somatic cell hybrids and a monoclonal anti-L antibody”. Hum. Genet. 74 (1): 34–40. DOI:10.1007/bf00278782. PMID 2944814.
- Levanon D, Danciger E, Dafni N, Groner Y (1987). „Genomic clones of the human liver-type phosphofructokinase”. Biochem. Biophys. Res. Commun. 141 (1): 374–80. DOI:10.1016/S0006-291X(86)80379-5. PMID 2948503.
- Vora S, Davidson M, Seaman C i dr.. (1984). „Heterogeneity of the molecular lesions in inherited phosphofructokinase deficiency”. J. Clin. Invest. 72 (6): 1995–2006. DOI:10.1172/JCI111164. PMC 437040. PMID 6227635.
- Vora S, Seaman C, Durham S, Piomelli S (1980). „Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system”. Proc. Natl. Acad. Sci. U.S.A. 77 (1): 62–6. DOI:10.1073/pnas.77.1.62. PMC 348208. PMID 6444721.
- Koster JF, Slee RG, Van Berkel TJ (1980). „Isoenzymes of human phosphofructokinase”. Clin. Chim. Acta 103 (2): 169–73. DOI:10.1016/0009-8981(80)90210-7. PMID 6445244.
- Vora S, Francke U (1981). „Assignment of the human gene for liver-type 6-phosphofructokinase isozyme (PFKL) to chromosome 21 by using somatic cell hybrids and monoclonal anti-L antibody”. Proc. Natl. Acad. Sci. U.S.A. 78 (6): 3738–42. DOI:10.1073/pnas.78.6.3738. PMC 319647. PMID 6455664.
- Zeitschel U, Bigl M, Eschrich K, Bigl V (1996). „Cellular distribution of 6-phosphofructo-1-kinase isoenzymes in rat brain”. J. Neurochem. 67 (6): 2573–80. DOI:10.1046/j.1471-4159.1996.67062573.x. PMID 8931492.
- Hattori M, Fujiyama A, Taylor TD i dr.. (2000). „The DNA sequence of human chromosome 21”. Nature 405 (6784): 311–9. DOI:10.1038/35012518. PMID 10830953.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L i dr.. (2004). „Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides”. Nat. Biotechnol. 21 (5): 566–9. DOI:10.1038/nbt810. PMID 12665801.
- Zhang C, Dowd DR, Staal A i dr.. (2003). „Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing”. J. Biol. Chem. 278 (37): 35325–36. DOI:10.1074/jbc.M305191200. PMID 12840015.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V i dr.. (2004). „Functional proteomics mapping of a human signaling pathway”. Genome Res. 14 (7): 1324–32. DOI:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA i dr.. (2005). „Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94–101. DOI:10.1038/nbt1046. PMID 15592455.