IRNK guanililtransferaza

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IRNK guanililtransferaza
Identifikatori
EC broj 2.7.7.50
CAS broj 56941-23-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

IRNK guanililtransferaza (EC 2.7.7.50, iRNK završavajući enzim, informaciona RNK guanililtransferaza, protein lambda 2) je enzim sa sistematskim imenom GTP:iRNK guanililtransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

GTP + (5')ppPur-iRNK difosfat + G(5')pppPur-iRNK

Ovaj enzim takođe može da modifikuje sintetički poli(A) i poli(G) čime formira strukture m7G(5')pppAn i m7G(5')pppGn.

Reference[uredi - уреди | uredi izvor]

  1. Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. (1975). "Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus". Proc. Natl. Acad. Sci. USA 72: 2525–2529. PMID 1058472. 
  2. Groner, Y., Gilbao, E. and Aviv, H. (1978). "Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates". Biochemistry 17: 977–982. PMID 629955. 
  3. Itoh, N., Yamada, H., Kaziro, Y. and Mizumoto, K. (1987). "Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization". J. Biol. Chem. 262: 1989–1995. PMID 3029058. 
  4. Martin, S.A. and Moss, B. (1975). "Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7)methyltransferase from vaccinia virions". J. Biol. Chem. 250: 9330–9335. PMID 1194287. 
  5. Martin, S.A., Paoletti, E. and Moss, B. (1975). "Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions". J. Biol. Chem. 250: 9322–9329. PMID 1194286. 

Literatura[uredi - уреди | uredi izvor]

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